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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Hispolon has been shown to possess antitumor effects in various cancer cells. However, the underlying mechanisms are not fully understood. In this study, we evaluated the sensitizing effect of hispolon on TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human renal carcinoma cells. Methods: Apoptosis was analyzed by using cell-based cytometer. The mRNA levels were assessed by reverse transcription-PCR. Bax activation was determined by oligomerization and fluorescence-activated cell sorting with Bax-NT monoclonal antibody. The protein expression was measured by Western blotting. Results: Hispolon induced up-regulation of Bim and death receptors expression at the post-translational level. Conclusions: Hispolon enhanced TRAIL-mediated apoptosis in renal carcinoma cells, but not in normal cells. (J Cancer Prev 2019;24:155-162)
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참고문헌 (26)
참고문헌 신청
Zhao Z / 2016 / Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway / Oncol Rep 35:896~904
Chang HY / 2011 / Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice / Evid Based Complement Alternat Med 2011:478246
Huang GJ / 2011 / Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation / J Agric Food Chem 59:7104~7113
Chen W / 2008 / Hispolon induces apoptosis in human gastric cancer cells through a ROSmediated mitochondrial pathway / Free Radic Biol Med 45:60~72
Hsiao PC / 2013 / Hispolon induces apoptosis through JNK1/2-mediated activation of a caspase-8, -9, and -3-dependent pathway in acute myeloid leukemia (AML) cells and inhibits AML xenograft tumor growth in vivo / J Agric Food Chem 61:10063~10073
Chang HY / 2011 / Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice / Evid Based Complement Alternat Med 2011:478246
Huang GJ / 2011 / Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation / J Agric Food Chem 59:7104~7113
Chen W / 2008 / Hispolon induces apoptosis in human gastric cancer cells through a ROSmediated mitochondrial pathway / Free Radic Biol Med 45:60~72
Hsiao PC / 2013 / Hispolon induces apoptosis through JNK1/2-mediated activation of a caspase-8, -9, and -3-dependent pathway in acute myeloid leukemia (AML) cells and inhibits AML xenograft tumor growth in vivo / J Agric Food Chem 61:10063~10073
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