지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Helicobacter pylori is recognized as a risk factor for gastric carcinogenesis. The chronic exposure of gastric epithelium to H. pylori induces a prolonged inflammatory state that may progress to gastric cancer. Astaxanthin, a pinkish antioxidant carotenoid, abundant in marine organisms, is known for its protective effect against inflammation and multiple types of cancer. The purpose of this study was to examine the effect of astaxanthin on H. pylori-induced oxidative injury, inflammation, and oncogene expression in gastric mucosal tissues of the infected mice. Mice were inoculated using oral gavage with H. pylori suspension (108 colony forming unit of H. pylori/0.1 mL) for three days, after which they were fed astaxanthin-supplemented diet (5 mg/kg body weight/day for seven weeks). The effects of astaxanthin on H. pylori-induced increase in lipid peroxide (LPO) production, myeloperoxidase (MPO) activity, expression of the inflammatory cytokine IFN-γ and oncogenes (c-myc and cyclin D1), and the accompanying histologic changes in gastric mucosal tissues were evaluated. H. pylori infection increased the level of LPO, MPO activity, and the expression of IFN-γ, c-myc, and cyclin D1 in gastric mucosal tissues of mice. H. pylori infection induced neutrophil infiltration and hyperplasia of gastric mucosa. Astaxanthin supplementation attenuated these effects. In conclusion, consumption of astaxanthin-rich foods may prevent H. pylori-associated oxidative damage and inflammatory and oncogenic responses in gastric mucosal tissues. Key Words Astaxanthin, Helicobacter pylori, Gastric mucosa, Inflammation, Oncogene
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참고문헌 (40)
참고문헌 신청
Butcher LD / 2017 / Oxidative stress resulting from Helicobacter pylori infection contributes to gastric carcinogenesis / Cell Mol Gastroenterol Hepatol 3:316~322
Bartchewsky W Jr / 2009 / Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer / Scand J Gastroenterol 44:153~161
Abdollahi H / 2011 / IL-10, TNF-α and IFN-γ levels in serum and stomach mucosa of Helicobacter pylori-infected patients / Iran J Allergy Asthma Immunol 10:267~271
Crabtree JE / 1995 / Helicobacter pylori and gastric mucosal cytokines : evidence that CagA-positive strains are more virulent / Lab Invest 73:742~745
Davies GR / 1994 / Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo / Gut 35:179~185
Bartchewsky W Jr / 2009 / Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer / Scand J Gastroenterol 44:153~161
Abdollahi H / 2011 / IL-10, TNF-α and IFN-γ levels in serum and stomach mucosa of Helicobacter pylori-infected patients / Iran J Allergy Asthma Immunol 10:267~271
Crabtree JE / 1995 / Helicobacter pylori and gastric mucosal cytokines : evidence that CagA-positive strains are more virulent / Lab Invest 73:742~745
Davies GR / 1994 / Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo / Gut 35:179~185
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