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논문 기본 정보

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저자정보
Omar Ibrahim Saadah (King Abdulaziz University Faculty of Medicine) Kholoud Bakur Fallatah (King Abdulaziz University Faculty of Medicine) Cedric Baumann (University Hospital of Nancy) Abdulrahman Ahmed Elbaradie (King Abdulaziz University Faculty of Medicine) Fatimah Talat Howladar (King Abdulaziz University Faculty of Medicine) Motaz Tariq Daiwali (King Abdulaziz University Faculty of Medicine) Omar Hamad Alshuaibi (King Abdulaziz University Faculty of Medicine) Majid Abdulaziz Alsahafi (King Abdulaziz University Faculty of Medicine) Rana Yaqoob Bokhary (King Abdulaziz University Faculty of Medicine) Yousef Abdulfattah Qari (King Abdulaziz University Faculty of Medicine) Laurent Peyrin-Biroulet (University Hospital of Nancy) Mahmoud Hisham Mosli (King Abdulaziz University Faculty of Medicine)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.18 No.2
발행연도
2020.1
수록면
210 - 218 (9page)

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Background/Aims: Crohn’s disease (CD) may involve the upper parts of the gastrointestinal (GI) tract including the esophagus, stomach, and duodenum. Clinical features of upper GI CD (UGICD) are not well characterized in the Gulf region. We therefore aimed to assess the prevalence and clinical characteristics of patients diagnosed with UGICD. Methods: We performed a retrospective analysis of all patients diagnosed with CD who underwent upper GI endoscopy between 2012 and 2017 at King Abdulaziz University Hospital, irrespective of age. Patients who had endoscopy of the upper GI tract at baseline and had histologically confirmed UGICD were included. Data on patients’ demographics, clinical characteristics, extraintestinal manifestations and complications were reviewed. Results: We identified 78 CD patients who underwent upper GI endoscopy from our medical records. The mean age was 17.2±8.7 years and 55.1% were males. Of the total, 19 out of 78 patients (24.4%) had histologically confirmed UGICD (3 esophageal, 16 gastric, and 9 duodenal), of which 52.6% were symptomatic. Disease distribution was ileal in 57.8%, colonic in 21.1% and ileo-colonic in 21.1%. A non-stricturing and non-penetrating phenotype was reported in 89.4%, stricturing in 5.3%, and penetrating in 5.3%. Perianal disease was found in 10.5%. UGICD was complicated by stricture formation in 2 patients (esophageal and gastric). Conclusions: The prevalence of UGICD is considered high among CD Saudi patients who undergo upper GI endoscopy at baseline, and is asymptomatic in 47.4% of patients. This reported prevalence is not dissimilar from reports originating from Western countries. (Intest Res 2020;18:210-218)
#Crohn disease #Inflammatory bowel disease #Esophagitis #Gastro-duodenal #Saudi Arabia

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참고문헌 신청
Kaser A / 2010 / Inflammatory bowel disease / Annu Rev Immunol 28:573~621 google schola Maaser C / 2019 / ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: initial diagnosis, monitoring of known IBD, detection of complications / J Crohns Colitis 13:144~164 google schola Schwartzberg DM / 2019 / Crohn’s disease of the esophagus, duodenum, and stomach / Clin Colon Rectal Surg 32:231~242 google schola Goodhand J / 2010 / Inflammatory bowel disease in young people : the case for transitional clinics / Inflamm Bowel Dis 16:947~952 google schola Ramaswamy K / 2003 / Esophageal Crohn disease in children : a clinical spectrum / J Pediatr Gastroenterol Nutr 36:454~458 google schola

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