Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing

Camstra Kevin M.; Srinivasan Visish M.; Collins Dalis; Chen Stephen; Kan Peter; Johnson Jeremiah

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자료유형: 학술저널

저자정보: Camstra Kevin M. (Baylor College of Medicine Houston TX USA) Srinivasan Visish M. (Baylor College of Medicine Houston TX USA) Collins Dalis (Baylor College of Medicine Houston TX USA) Chen Stephen (Baylor College of Medicine Houston TX USA) Kan Peter (Baylor College of Medicine Houston TX USA) Johnson Jeremiah (Baylor College of Medicine Houston TX USA)

저널정보: 대한신경중재치료의학회 Neurointervention Neurointervention Vol.15 No.3

발행연도: 2020.1

수록면: 107 - 116 (10page)

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Purpose: With advancing endovascular technology and increasing interest in minimally invasive intra-arterial therapies such as stem cell and chemotherapy for cerebral disease, the establishment of a translational model with cerebral circulation accessible to microcatheters is needed. We report our experience catheterizing canine cerebral circulation with microcatheters, present high-resolution angiographic images of the canine vascular anatomy, describe arterial branch flow patterns and provide measurements of canine arterial conduits.Materials and Methods: Angiograms were performed on 10 intact purpose-bred hounds. Angiography, measurements of arterial conduits and catheterization information for intracranial arterial branches were obtained.Results: Selective and superselective cerebral angiography was successful in all subjects. Relevant arterial mean diameters include the femoral (4.64 mm), aorta (9.38 mm), external carotid (3.65 mm), internal carotid arteries (1.6 mm), vertebrobasilar system and Circle of Willis branches. Catheterization of the Circle of Willis was achieved via the posterior circulation in all subjects tested (n=3) and the use of flow directed microcatheters resulted in reduced arterial tree deformation and improved superselection of intracranial vessels. Catheterization of the intracranial circulation was attempted but not achieved via the internal carotid artery (n=7) due to its tortuosity and subsequent catheter related vasospasm.Conclusion: The canine cerebral vasculature is posterior circulation dominant. Anterior circulation angiography is achievable via the internal carotid artery, but direct cerebral arterial access is best achieved via the posterior circulation using flow-directed microcatheters. It is feasible to deliver intra-arterial therapies to selective vascular territories within the canine cerebral circulation, thus making it a viable animal model for testing novel intra-arterial cerebral treatments.

#Angiography #Animal model #Intraarterial delivery #Neurovascular

참고문헌 (23)

참고문헌 신청

Guzman R / 2018 / Intra-arterial delivery of cell therapies for stroke / Stroke 49:1075~1082

Misra V / 2012 / Intra-arterial delivery of cell therapies for stroke / Stem Cells Dev 21:1007~1015

Moniche F / 2015 / Intra-arterial bone marrow mononuclear cells(BM-MNCs)transplantation in acute ischemic stroke(IBIS trial) : protocol of a phase II, randomized, dose-finding, controlled multicenter trial / Int J Stroke 10:1149~1152

Silachev DN / 2015 / Intra-arterial administration of multipotent mesenchymal stromal cells promotes functional recovery of the brain after traumatic brain injury / Bull Exp Biol Med 159:528~533

Spiliopoulos S / 2019 / Incidence and endovascular treatment of severe spontaneous non-cerebral bleeding : a single-institution experience / Eur Radiol 29:3296~3307

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