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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 20 - 31 (12page)
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초록· 키워드
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The receptor of vitamin D is expressed in almost all body cells, including vascular endothelial cells and cardiomyocytes. Vitamin D deficiency has been observed widespread amongst heart failure (HF) patients, which could have harmful effects on their health condition. This study aims to investigate the effect of vitamin D supplements on blood pressure (BP) and physical activity of HF patients. Thirty-nine systolic HF patients with low ejection fraction (EF) < 50% and class III of New York Heart Association functional classification were randomly divided into 2 groups including intervention and placebo to enroll in an 8 weeks double-blind clinical trial. During the trial 6-minute walk test (6MWT), 25-hydroxyvitamin D (25[OH]D) level, BP, sodium and potassium intakes were assessed. The mean 25(OH)D level increased to 28.9 ± 11.7 ng/mL (p < 0.001) in the intervention group. There was a poor but non-significant reduction in systolic BP (−0.033 ± 4.71 mmHg, p = 0.531) in the intervention group. The BP also did not change in the placebo group at the end of the trial. A negligible decrease of 6MWT was observed in the intervention group (−6.6 ± 29.2 m) compared to the placebo (−14.1 ± 40.5 m). However, differences between the 2 groups were not statistically significant (p = 0.325). The results solely showed a slight positive correlation between 25(OH)D level and 6MWT. No significant improvements in BP and 6MWT were observed after vitamin D3 supplementation.
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참고문헌 (52)
참고문헌 신청
Don-Wauchope AC / 2015 / Evidence based application of BNP/NT-proBNP testing in heart failure / Clin Biochem 48:236~246
Mosterd A / 2007 / Clinical epidemiology of heart failure / Heart 93:1137~1146
Dalbeni A / 2014 / Effects of six months of vitamin D supplementation in patients with heart failure : a randomized double-blind controlled trial / Nutr Metab Cardiovasc Dis 24:861~868
Writing Committee Members / 2013 / ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines / Circulation 128:e240~e327
Hill SA / 2014 / Use of BNP and NT-proBNP for the diagnosis of heart failure in the emergency department : a systematic review of the evidence / Heart Fail Rev 19:421~438
Mosterd A / 2007 / Clinical epidemiology of heart failure / Heart 93:1137~1146
Dalbeni A / 2014 / Effects of six months of vitamin D supplementation in patients with heart failure : a randomized double-blind controlled trial / Nutr Metab Cardiovasc Dis 24:861~868
Writing Committee Members / 2013 / ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines / Circulation 128:e240~e327
Hill SA / 2014 / Use of BNP and NT-proBNP for the diagnosis of heart failure in the emergency department : a systematic review of the evidence / Heart Fail Rev 19:421~438
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