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논문 기본 정보

자료유형
학술저널
저자정보
Aida Torkzaban (Isfahan University of Medical Sciences) Amirmansour Alavi Naeini (Isfahan University of Medical Sciences) Akbar Hassanzadeh (Isfahan University of Medical Sciences) Mehrdad Namdari (Lorestan University of Medical Sciences)
저널정보
한국임상영양학회 Clinical Nutrition Research Clinical Nutrition Research Vol.9 No.4
발행연도
2020.1
수록면
307 - 317 (11page)

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Coronary artery disease (CAD) is among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are affecting factors in the progress of atherosclerosis. The aim of this study was to measure serum levels of uric acid (UA) and vitamin C as well as the antioxidant status in patients with CAD, and compared them with those in healthy individuals. The present case-control study was performed on 44 cases and 44 controls. Demographic data and anthropometric indices were measured. The Food Frequency Questionnaire (FFQ) and International Physical Activity Questionnaire (IPAQ) were completed. After 12 hours of fasting,10 mL blood was sampled from the participants. Serum levels of UA, vitamin C, Total Antioxidant Capacity (TAC) and Malondialdehyde (MDA) were also measured. The data were finally analyzed by SPSS v22. A significant difference was observed between the groups in terms of UA and vitamin C. However, mean levels of MDA and TAC were not significantly different between groups. The differences between groups in terms of vitamin A, vitamin E, beta-carotene, zinc and selenium intakes were not significant either. A significant difference was detected between the groups in terms of vitamin C intake. Our results suggest that increase in UA and decrease in vitamin C in serum levels can be considered as risk factors for CAD patients. Due to a lack of any significant correlation between TAC and CAD risk in this study, further study with bigger sample size is needed.
#Ascorbic acid #Uric acid #Atherosclerosis #Coronary artery disease

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참고문헌 (47)

참고문헌 신청
Sanchis-Gomar F / 2016 / Epidemiology of coronary heart disease and acute coronary syndrome / Ann Transl Med 4:256 google schola Nabati M / 2013 / Relationship between the level of serum uric acid and severity of coronary artery atherosclerosis determined by coronary angiography in patients with chronic stable / Majallahi Danishgahi Ulumi Pizishkii Mazandaran 23:19~26 google schola Chiha M / 2012 / Diabetes and coronary heart disease : a risk factor for the global epidemic / Int J Hypertens 2012:697240 google schola Boroumand MA / 2008 / Correlation between lipoprotein(a)serum concentration and severity of coronary artery stenosis in an Iranian population according to Gensini score / Clin Biochem 41:117~120 google schola Daniel M / 2017 / Effect of myocardial infarction with nonobstructive coronary arteries on physical capacity and quality-of-life / Am J Cardiol 120:341~346 google schola

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