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논문 기본 정보

자료유형
학술저널
저자정보
Akira Minematsu (Department of Physical Therapy Faculty of Health) Tomoko Hanaoka (Division of Health Science Graduate School of Health Science Kio University 4-2-2 Umaminaka Kory) Yoshihiro Takada (Division of Health Science Graduate School of Health Science Kio University 4-2-2 Umaminaka Kory) Shunji Okuda (Department of Modern Education Faculty of Education Kio University 4-2-2 Umaminaka Koryo-cho Ki) Hidetaka Imagita (Department of Physical Therapy Faculty of Health Science Kio University) Susumu Sakata (Department of Physiology Nara Medical University 840 Shijo-cho Kashihara Nara 634-8521 Japan)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.2 No.1
발행연도
2016.1
수록면
25 - 29 (5page)

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Objectives: Type 2 diabetes mellitus (T2DM) increases fracture risk despite normal to high levels of bone mineral density. Bone quality is known to affect bone fragility in T2DM. The aim of this study was to clarify the trabecular bone microstructure and cortical bone geometry of the femur in T2DM model rats. Methods: Five-week-old Otsuka Long-Evans Tokushima Fatty (OLETF; n ¼ 5) and Long-Evans Tokushima Otsuka (LETO; n ¼ 5) rats were used. At the age of 18 months, femurs were scanned with micro-computed tomography, and trabecular bone microstructure and cortical bone geometry were analyzed. Results: Trabecular bone microstructure and cortical bone geometry deteriorated in the femur in OLETF rats. Compared with in LETO rats, in OLETF rats, bone volume fraction, trabecular number and connectivity density decreased, and trabecular space significantly increased. Moreover, in OLETF rats, cortical bone volume and section area decreased, and medullary volume significantly increased. Conclusions: Long-term T2DM leaded to deterioration in trabecular and cortical bone structure. Therefore, OLETF rats may serve as a useful animal model for investigating the relationship between T2DM and bone quality. © 2016 The Korean Society of Osteoporosis. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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