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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.8 No.1
- 발행연도
- 2018.1
- 수록면
- 127 - 136 (10page)
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Neural interfaces have great potential to treat disease and disability by modulating the electrical signals within the nervoussystem. However, whilst neural stimulation is a well-established technique, current neural interfaces are limited by poorrecording ability. Low signal amplitudes necessitate the use of highly invasive techniques that divide or penetrate thenerve, and as such are unsuitable for chronic implantation. In this paper, we present the first application of the velocityselective recording technique to the detection of respiration activity in the vagus nerve, which is involved with treatmentsfor epilepsy, depression, and rheumatoid arthritis. Further, we show this using a chronically implantable interface that doesnot divide the nerve. We also validate our recording setup using electrical stimulation and we present an analysis of therecorded signal amplitudes. The recording interface was formed from a cuff containing ten electrodes implanted around theintact right vagus nerve of a Danish Landrace pig. Nine differential amplifiers were connected to adjacent electrodes, andthe resulting signals were processed to discriminate neural activity based on conduction velocity. Despite the averagesingle channel signal-to-noise ratio of - 5.8 dB, it was possible to observe distinct action potentials travelling in bothdirections along the nerve. Further, contrary to expectation given the low signal-to-noise ratio, we have shown that it waspossible to identify afferent neural activity that encoded respiration. The significance of this is the demonstration of achronically implantable method for neural recording, a result that will transform the capabilities of future neuroprostheses.
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참고문헌 (17)
참고문헌 신청
Schuettler M / 2013 / Fibre-selective recording from the peripheral nerves of frogs using a multielectrode cuff / J Neural Eng 10:36016
Schuettler M / 2011 / Fibre-selective recording from peripheral nerves using a multiple-contact cuff: report on pilot pig experiments / Conf Proc IEEE Eng Med Biol Soc 2011:3103~3106
Metcalfe BW / 2015 / A new method for spike extraction using velocity selective recording demonstrated with physiological ENG in rat / J Neurosci Methods 251:47~55
Connor DE / 2012 / Vagal nerve stimulation for the treatment of medically refractory epilepsy: a review of the current literature / Neurosurg Focus 32:E12
George MS / 2000 / Vagus nerve stimulation: a new tool for brain research and therapy / Biol Psychiatry 47:287~295
Schuettler M / 2011 / Fibre-selective recording from peripheral nerves using a multiple-contact cuff: report on pilot pig experiments / Conf Proc IEEE Eng Med Biol Soc 2011:3103~3106
Metcalfe BW / 2015 / A new method for spike extraction using velocity selective recording demonstrated with physiological ENG in rat / J Neurosci Methods 251:47~55
Connor DE / 2012 / Vagal nerve stimulation for the treatment of medically refractory epilepsy: a review of the current literature / Neurosurg Focus 32:E12
George MS / 2000 / Vagus nerve stimulation: a new tool for brain research and therapy / Biol Psychiatry 47:287~295
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