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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.10 No.3
- 발행연도
- 2018.1
- 수록면
- 225 - 235 (11page)
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Purpose: Severe asthma and asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) are difficult to control and are often associated with poor clinical outcomes. However, much is not understood regarding the diagnosis and treatment of severe asthma and ACOS. To evaluate the current perceptions of severe asthma and COPD among asthma and COPD specialists, we designed an e-mail and internet-based questionnaire survey. Methods: Subjects were selected based on clinical specialty from among the members of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Academy of Tuberculosis and Respiratory Diseases. Of 432 subjects who received an e-mail invitation to the survey, 95 subjects, including 58 allergists and 37 pulmonologists, responded and submitted their answers online. Results: The specialists estimated that the percentage of severe cases among total asthma patients in their practice was 13.9%±11.0%. Asthma aggravation by stepping down treatment was the most common subtype, followed by frequent exacerbation, uncontrolled asthma despite higher treatment steps, and serious exacerbation. ACOS was estimated to account for 20.7% of asthma, 38.0% of severe asthma, and 30.1% of COPD cases. A history of smoking, persistently low forced expiratory volume in 1 second (FEV1), and low FEV1 variation were most frequently classified as the major criteria for the diagnosis of ACOS among asthma patients. Among COPD patients, the highly selected major criteria for ACOS were high FEV1 variation, positive bronchodilator response, a personal history of allergies and positive airway hyperresponsiveness. Allergists and pulmonologists showed different assessments and opinions on asthma phenotyping, percentage, and diagnostic criteria for ACOS. Conclusions: Specialists had diverse perceptions and clinical practices regarding severe asthma and ACOS patients. This heterogeneity must be considered in future studies and strategy development for severe asthma and ACOS.
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참고문헌 (49)
참고문헌 신청
Chung KF / 2014 / International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma / Eur Respir J 43:343~373
Bousquet J / 2010 / Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma / J Allergy Clin Immunol 126:926~938
Custovic A / 2013 / EAACI position statement on asthma exacerbations and severe asthma / Allergy 68:1520~1531
Sullivan SD / 2007 / Association of control and risk of severe asthma-related events in severe or difficult-to-treat asthma patients / Allergy 62:655~660
Gibson PG / 2009 / The overlap syndrome of asthma and COPD: what are its features and how important is it? / Thorax 64:728~735
Bousquet J / 2010 / Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma / J Allergy Clin Immunol 126:926~938
Custovic A / 2013 / EAACI position statement on asthma exacerbations and severe asthma / Allergy 68:1520~1531
Sullivan SD / 2007 / Association of control and risk of severe asthma-related events in severe or difficult-to-treat asthma patients / Allergy 62:655~660
Gibson PG / 2009 / The overlap syndrome of asthma and COPD: what are its features and how important is it? / Thorax 64:728~735
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