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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 98 - 105 (8page)
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This study was undertaken to investigate the antioxidant/oxidant status in recurrent miscarriage patients. Antioxidants including glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR), reduced glutathione (GSH) and selenium (Se), as well as the oxidants hydrogen peroxide (H2O2), oxidised glutathione (GSSG) and lipid peroxidation were assayed in plasma, whole blood and placental tissue of non-pregnant women (NP), healthy pregnant women (HP), and recurrent miscarriage (RM) patients. Results indicated that all antioxidant activities and levels in plasma and whole blood of HP women were consistently moderately lower, and much more significantly lower in RM patients when both were compared to those seen in NP women (P < 0.05 and P < 0.001, respectively). Furthermore, whereas plasma antioxidant activities and levels were significantly lower in RM patients, those of whole blood and placental tissue were much more significantly lower when compared with HP women (P < 0.001). Concurrent with these findings there were consistent increases of equal statistical significance and magnitude in the levels of all investigated oxidants assayed in all samples when compared in between subjects of the study as indicated above. Data thus illustrated a distinct shift in favor of oxidative reactions and reactive oxygen species (ROS) generation, and very significant decreases in the GSH/ GSSG ratios in whole blood and placental tissue of RM patients when compared to HP and NP women (P < 0.001). The above noted oxidative stress could have been a major causative factor of recurrent miscarriage.
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참고문헌 (40)
참고문헌 신청
Agarwal A / 2008 / Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications / Antioxid Redox Signal 10:1375~1403
Stadtman ER / 2000 / Protein oxidation / Ann NY Acad Sci 899:191~208
Aboul-Soud MA / 2011 / Hepatoprotective effects of vitamin E/selenium against malathion induced injuries on the antioxidant status and apoptosis-related gene expression in rats / J Toxicol Sci 36:285~296
Al-Sheikh YA / 2011 / The effect of micronutrients on superoxide dismutase in senescent fibroblasts / Cell Biochem Funct 29:384~393
Ghneim HK / 2011 / Effect of selenium supplementation on glutathione peroxidase and catalase activities in senescent cultured human fibroblasts / Ann Nutr Metab 59:127~138
Stadtman ER / 2000 / Protein oxidation / Ann NY Acad Sci 899:191~208
Aboul-Soud MA / 2011 / Hepatoprotective effects of vitamin E/selenium against malathion induced injuries on the antioxidant status and apoptosis-related gene expression in rats / J Toxicol Sci 36:285~296
Al-Sheikh YA / 2011 / The effect of micronutrients on superoxide dismutase in senescent fibroblasts / Cell Biochem Funct 29:384~393
Ghneim HK / 2011 / Effect of selenium supplementation on glutathione peroxidase and catalase activities in senescent cultured human fibroblasts / Ann Nutr Metab 59:127~138
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