지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,345 - 1,348 (4page)
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초록· 키워드
오류제보하기
Wilson’s disease typically presents symptoms associated with liver damage or neuropsychiatric disturbances, while endocrinologic abnormalities are rare. We report an unprecedented case of hypopituitarism in a patient with Wilson’s disease. A 40-year-old woman presented with depression, general weakness and anorexia. Laboratory tests and imaging studies were compatible with liver cirrhosis due to Wilson’s disease. Basal hormone levels and pituitary function tests indicated secondary hypothyroidism and adrenal insufficiency due to hypopituitarism. Brain MRI showed T2 hyperintense signals in both basal ganglia and midbrain but the pituitary imaging was normal. She is currently receiving chelation therapy along with thyroid hormone and steroid replacement. There may be a relationship between Wilson’s disease and hypopituitarism. Copper deposition or secondary neuronal damage in the pituitary may be a possible explanation for this theory.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Krysiak R / 2012 / Endocrine symptoms as the initial manifestation of Wilson’s disease / Yale J Biol Med 85:249~254
이상윤 / 2013 / A Case of Colonic Adenocarcinoma in a Patient with Wilson’s Disease / Gut and Liver 7(4):500~503
Lewis AS / 2009 / All patients with ‘idiopathic’ hypopituitarism should be screened for hemochromatosis / Pituitary 12:273~275
Wilson V / 2014 / The causes of hypopituitarism in the absence of abnormal pituitary imaging / QJM 107:21~24
Kim JM / 2005 / Ferrous and ferric iron accumulates in the brain of aged Long-Evans Cinnamon rats, an animal model of Wilson’s disease / Neurosci Lett 382:143~147
이상윤 / 2013 / A Case of Colonic Adenocarcinoma in a Patient with Wilson’s Disease / Gut and Liver 7(4):500~503
Lewis AS / 2009 / All patients with ‘idiopathic’ hypopituitarism should be screened for hemochromatosis / Pituitary 12:273~275
Wilson V / 2014 / The causes of hypopituitarism in the absence of abnormal pituitary imaging / QJM 107:21~24
Kim JM / 2005 / Ferrous and ferric iron accumulates in the brain of aged Long-Evans Cinnamon rats, an animal model of Wilson’s disease / Neurosci Lett 382:143~147
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