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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 315 - 320 (6page)
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The diagnosis of hepatocellular carcinoma (HCC) is based on imaging studies particularly in high-risk patients without histologic confirmation. This study evaluated the prevalence and characteristics of false-positively diagnosed HCC in a liver resection cohort for HCC. A retrospective review was performed of 837 liver resection cases for clinically diagnosed HCC between 2005 and 2010 at our institute. High-risk patients with tumors > 1 cm with one or two image findings consistent with HCC and tumors < 1 cm with two or more image findings consistent with HCC with persistently increased serum alpha-fetoprotein (AFP) levels above the normal range with underlying inhibited hepatitis activity underwent liver resection. The false-positive rate was 2.2% (n = 18). Of the 18 patients, 7 patients (0.8%) were diagnosed with benign conditions (one each of hemangioma, inflammation, cortical adenoma, dysplastic nodule, angiomyolipoma, bile duct adenoma, and non-neoplastic liver parenchyme) and 11 patients (1.3%) were diagnosed with malignancies (cholangiocarcinoma [n = 6], hepatoblastoma [n = 2], and one each of lymphoepithelioma-like carcinoma, ovarian cystadenocarcinoma, and nasopharynx carcinoma metastasis). The clinical characteristics of pathologically diagnosed HCC patients were similar (P > 0.05) compared to non-HCC patients except for higher rate of history of alcoholism (P < 0.05) observed in non-HCC patients. Four of 18 non-HCC patients (22.2%) showed diagnostic discordance on the dynamic imaging study. Despite the recent progression in diagnostic imaging techniques, 2.2% of cases were false-positively diagnosed as HCC in a liver resection patient cohort; and the final diagnosis was benign disease in 0.8% of liver resection patients clinically diagnosed with HCC.
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참고문헌 (10)
참고문헌 신청
한국 간 암 스터디그룹 / 2015 / 2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma / Gut and Liver 9(3):267~317
Choi BI / 2010 / Advancement in HCC imaging: diagnosis, staging and treatment efficacy assessments: imaging diagnosis and staging of hepatocellular carcinoma / J Hepatobiliary Pancreat Sci 17:369~373
Lee JM / 2012 / Recent advances in CT and MR imaging for evaluation of hepatocellular carcinoma / Liver Cancer 1:22~40
Chou R / 2015 / Imaging techniques for the diagnosis of hepatocellular carcinoma : a systematic review and meta-analysis / Ann Intern Med 162:697~711
European Association for the Study of the Liver / 2012 / European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
Choi BI / 2010 / Advancement in HCC imaging: diagnosis, staging and treatment efficacy assessments: imaging diagnosis and staging of hepatocellular carcinoma / J Hepatobiliary Pancreat Sci 17:369~373
Lee JM / 2012 / Recent advances in CT and MR imaging for evaluation of hepatocellular carcinoma / Liver Cancer 1:22~40
Chou R / 2015 / Imaging techniques for the diagnosis of hepatocellular carcinoma : a systematic review and meta-analysis / Ann Intern Med 162:697~711
European Association for the Study of the Liver / 2012 / European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
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