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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 750 - 756 (7page)
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Mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells are known to play important roles in autoimmunity, infectious diseases and cancers. However, little is known about the roles of these invariant T cells in multiple trauma. The purposes of this study were to examine MAIT and NKT cell levels in patients with multiple trauma and to investigate potential relationships between these cell levels and clinical parameters. The study cohort was composed of 14 patients with multiple trauma and 22 non-injured healthy controls (HCs). Circulating MAIT and NKT cell levels in the peripheral blood were measured by flow cytometry. The severity of injury was categorised according to the scoring systems, such as Acute Physiology and Chronic Health Evaluation (APACHE) II score, Simplified Acute Physiology Score (SAPS) II, and Injury Severity Score (ISS). Circulating MAIT and NKT cell numbers were significantly lower in multiple trauma patients than in HCs. Linear regression analysis showed that circulating MAIT cell numbers were significantly correlated with age, APACHE II, SAPS II, ISS category, hemoglobin, and platelet count. NKT cell numbers in the peripheral blood were found to be significantly correlated with APACHE II, SAPS II, and ISS category. This study shows numerical deficiencies of circulating MAIT cells and NKT cells in multiple trauma. In addition, these invariant T cell deficiencies were found to be associated with disease severity. These findings provide important information for predicting the prognosis of multiple trauma.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Karakuş A / 2012 / The relationship of trauma severity and mortality with cardiac enzymes and cytokines at multiple trauma patients / Ulus Travma Acil Cerrahi Derg 18:289~295
Mannick JA / 2001 / The immunologic response to injury / J Am Coll Surg 193:237~244
Baue AE / 1998 / Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? / Shock 10:79~89
Szabo PA / 2015 / CD1d-and MR1-restricted T cells in sepsis / Front Immunol 6:401
Lantz O / 1994 / An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8-T cells in mice and humans / J Exp Med 180:1097~1106
Mannick JA / 2001 / The immunologic response to injury / J Am Coll Surg 193:237~244
Baue AE / 1998 / Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? / Shock 10:79~89
Szabo PA / 2015 / CD1d-and MR1-restricted T cells in sepsis / Front Immunol 6:401
Lantz O / 1994 / An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8-T cells in mice and humans / J Exp Med 180:1097~1106
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