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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
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- 1 - 7 (7page)
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For patients at risk of premature ovarian failure with cancer treatment, it is an important option to re-implant the ovarian tissue (OT) after cryopreservation to preserve endocrine function and fertility. With this technique, about 30% of pregnancy success rate and about 90 live births have been reported to date. However, there has been no case report of successful in vitro fertilization (IVF) and embryo transfer (ET) with oocytes collected from transplanted cryopreserved OT in Korea. We report a 30-year old woman with rectal cancer who underwent IVF and ET after cryopreserved OT thawing and re-implantation. She has been diagnosed with stage IIIC rectal cancer after surgery, and right ovary was removed and cryopreserved between cycles of chemotherapy. After completion of chemotherapy and radiotherapy, the patient underwent orthotopic transplantation of cryopreserved OTs. Three months after transplantation, the serum follicle-stimulating hormone level decreased from 91.11 mIU/mL to 43.69 mIU/mL. Thereafter, the patient underwent 11 ovarian stimulation cycles, and in 7 cycles, follicle growth was observed at the OT graft site. In one of these cycles, the oocyte was successfully retrieved and one embryo was transplanted after IVF. The patient was not pregnant, but the cryopreservation of OT can save the fertility after anticancer chemotherapy.
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참고문헌 (20)
참고문헌 신청
Tiong V / 2014 / Incidence of chemotherapy-induced ovarian failure in premenopausal women undergoing chemotherapy for breast cancer / World J Surg 38(9):2288~2296
Howell S / 1998 / Gonadal damage from chemotherapy and radiotherapy / Endocrinol Metab Clin North Am 27(4):927~943
Critchley HO / 2005 / Impact of cancer treatment on uterine function / J Natl Cancer Inst Monogr (34):64~68
So-Youn Kim / 2016 / Toward precision medicine for preserving fertility in cancer patients: existing and emerging fertility preservation options for women / Journal of Gynecologic Oncology 27(2):1~18
Donnez J / 2004 / Live birth after orthotopic transplantation of cryopreserved ovarian tissue / Lancet 364(9443):1405~1410
Howell S / 1998 / Gonadal damage from chemotherapy and radiotherapy / Endocrinol Metab Clin North Am 27(4):927~943
Critchley HO / 2005 / Impact of cancer treatment on uterine function / J Natl Cancer Inst Monogr (34):64~68
So-Youn Kim / 2016 / Toward precision medicine for preserving fertility in cancer patients: existing and emerging fertility preservation options for women / Journal of Gynecologic Oncology 27(2):1~18
Donnez J / 2004 / Live birth after orthotopic transplantation of cryopreserved ovarian tissue / Lancet 364(9443):1405~1410
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