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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 12 (12page)
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Background: Vitamin K antagonist (VKA) to prevent thromboembolism in non-valvular atrial fibrillation (NVAF) patients has limitations such as drug interaction. This study investigated the clinical characteristics of Korean patients treated with VKA for stroke prevention and assessed quality of VKA therapy and treatment satisfaction. Methods: We conducted a multicenter, prospective, non-interventional study. Patients with CHADS2 ≥ 1 and treated with VKA (started within the last 3 months) were enrolled from April 2013 to March 2014. Demographic and clinical features including risk factors of stroke and VKA treatment information was collected at baseline. Treatment patterns and international normalized ratio (INR) level were evaluated during follow-up. Time in therapeutic range (TTR) > 60% indicated well-controlled INR. Treatment satisfaction on the VKA use was measured by Treatment Satisfaction Questionnaire for Medication (TSQM) after 3 months of follow-up. Results: A total of 877 patients (age, 67; male, 60%) were enrolled and followed up for one year. More than half of patients (56%) had CHADS2 ≥ 2 and 83.6% had CHA2DS2-VASc ≥ 2. A total of 852 patients had one or more INR measurement during their follow-up period. Among those patients, 25.5% discontinued VKA treatment during follow-up. Of all patients, 626 patients (73%) had poor-controlled INR (TTR < 60%) measure. Patients' treatment satisfaction measured with TSQM was 55.6 in global satisfaction domain. Conclusion: INR was poorly controlled in Korean NVAF patients treated with VKA. VKA users also showed low treatment satisfaction.
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참고문헌 (33)
참고문헌 신청
Jeong Joon Hoon / 2005 / Prevalence of and Risk Factors for Atrial Fibrillation in Korean Adults Older than 40 Years / Journal of Korean Medical Science 20(1):26
Marinigh R / 2010 / Age as a risk factor for stroke in atrial fibrillation patients: implications for thromboprophylaxis / J Am Coll Cardiol 56(11):827~837
Go AS / 2001 / Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study / JAMA 285(18):2370~2375
Diringer MN / 1999 / Predictors of acute hospital costs for treatment of ischemic stroke in an academic center / Stroke 30(4):724~728
Dulli DA / 2003 / Atrial fibrillation is associated with severe acute ischemic stroke / Neuroepidemiology 22(2):118~123
Marinigh R / 2010 / Age as a risk factor for stroke in atrial fibrillation patients: implications for thromboprophylaxis / J Am Coll Cardiol 56(11):827~837
Go AS / 2001 / Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study / JAMA 285(18):2370~2375
Diringer MN / 1999 / Predictors of acute hospital costs for treatment of ischemic stroke in an academic center / Stroke 30(4):724~728
Dulli DA / 2003 / Atrial fibrillation is associated with severe acute ischemic stroke / Neuroepidemiology 22(2):118~123
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