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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 379 - 385 (7page)
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초록· 키워드
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Autoimmune thyroid disease (AITD) includes hyperthyroid Graves disease, hypothyroid autoimmune thyroiditis, and subtle subclinicalthyroid dysfunctions. AITD is caused by interactions between genetic and environmental predisposing factors and results inautoimmune deterioration. Data on polymorphisms in the AITD susceptibility genes, related environmental factors, and dysregulationof autoimmune processes have accumulated over time. Over the last decade, there has been progress in the clinical field ofAITD with respect to the available diagnostic and therapeutic methods as well as clinical consensus. The updated clinical guidelinesallow practitioners to identify the most reasonable and current approaches for proper management. In this review, we focus on recentadvances in understanding the genetic and environmental pathogenic mechanisms underlying AITD and introduce the updated set ofclinical guidelines for AITD management. We also discuss other aspects of the disease such as management of subclinical thyroiddysfunction, use of levothyroxine plus levotriiodothyronine in the treatment of autoimmune hypothyroidism, risk assessment oflong-standing antithyroid drug therapy in recurrent Graves’ hyperthyroidism, and future research needs.
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참고문헌 (55)
참고문헌 신청
Antonelli A / 2015 / Autoimmune thyroid disorders / Autoimmun Rev 14:174~180
Brand OJ / 2009 / Association of the thyroid stimulating hormone receptor gene(TSHR)with Graves’ disease / Hum Mol Genet 18:1704~1713
Colobran R / 2011 / Association of an SNP with intrathymic transcription of TSHR and Graves’ disease : a role for defective thymic tolerance / Hum Mol Genet 20:3415~3423
Nagamine K / 1997 / Positional cloning of the APECED gene / Nat Genet 17:393~398
Cetani F / 2001 / A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis / J Clin Endocrinol Metab 86:4747~4752
Brand OJ / 2009 / Association of the thyroid stimulating hormone receptor gene(TSHR)with Graves’ disease / Hum Mol Genet 18:1704~1713
Colobran R / 2011 / Association of an SNP with intrathymic transcription of TSHR and Graves’ disease : a role for defective thymic tolerance / Hum Mol Genet 20:3415~3423
Nagamine K / 1997 / Positional cloning of the APECED gene / Nat Genet 17:393~398
Cetani F / 2001 / A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis / J Clin Endocrinol Metab 86:4747~4752
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