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자료유형
학술저널
저자정보
이덕희 (경북대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.33 No.1
발행연도
2018.1
수록면
44 - 52 (9page)

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Evidence has emerged that endocrine-disrupting chemicals (EDCs) can produce adverse effects, even at low doses that are assumedsafe. However, systemic reviews and meta-analyses focusing on human studies, especially of EDCs with short half-lives, have demonstratedinconsistent results. Epidemiological studies have insuperable methodological limitations, including the unpredictable neteffects of mixtures, non-monotonic dose-response relationships, the non-existence of unexposed groups, and the low reliability of exposureassessment. Thus, despite increases in EDC-linked diseases, traditional epidemiological studies based on individual measurementsof EDCs in bio-specimens may fail to provide consistent results. The exposome has been suggested as a promising approach toaddress the uncertainties surrounding human studies, but it is never free from these methodological issues. Although exposure toEDCs during critical developmental periods is a major concern, continuous exposure to EDCs during non-critical periods is also harmful. Indeed, the evolutionary aspects of epigenetic programming triggered by EDCs during development should be considered becauseit is a key mechanism for developmental plasticity. Presently, living without EDCs is impossible due to their omnipresence. Importantly,there are lifestyles which can increase the excretion of EDCs or mitigate their harmful effects through the activation of mitohormesisor xenohormesis. Effectiveness of lifestyle interventions should be evaluated as practical ways against EDCs in the real world.

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