지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 12 - 21 (10page)
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Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue. The inducible brown adipocyte, beige adipocyte evolving by thermogenic activation of white adipose tissue have different origin and molecular signature from classical brown adipocytes but share the characteristics of high mitochondria content, UCP1 expression and thermogenic capacity when activated. Increasing browning may also be an efficient way to increase whole brown fat activity. Recent human studies have shown possibilities that findings in mice can be reproduced in human, making brown fat a good candidate organ to treat obesity and its related disorders.
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참고문헌 (68)
참고문헌 신청
Jensen MD / 2014 / 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society / Circulation 129(25 Suppl 2):S102~S138
Apovian CM / 2015 / Pharmacological management of obesity: an endocrine Society clinical practice guideline / J Clin Endocrinol Metab 100:342~362
Kershaw EE / 2004 / Adipose tissue as an endocrine organ / J Clin Endocrinol Metab 89:2548~2556
Harms M / 2013 / Brown and beige fat: development, function and therapeutic potential / Nat Med 19:1252~1263
Cypess AM / 2009 / Identification and importance of brown adipose tissue in adult humans / N Engl J Med 360:1509~1517
Apovian CM / 2015 / Pharmacological management of obesity: an endocrine Society clinical practice guideline / J Clin Endocrinol Metab 100:342~362
Kershaw EE / 2004 / Adipose tissue as an endocrine organ / J Clin Endocrinol Metab 89:2548~2556
Harms M / 2013 / Brown and beige fat: development, function and therapeutic potential / Nat Med 19:1252~1263
Cypess AM / 2009 / Identification and importance of brown adipose tissue in adult humans / N Engl J Med 360:1509~1517
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