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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 265 - 274 (10page)
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초록· 키워드
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patients and institutions. We are developing a glucose area under the curve (AUC) monitoring system without blood sampling using a minimally invasive interstitial fluid extraction technology (MIET). Here we evaluated the accuracy of interstitial fluid glucose (IG) AUC measured by MIET in patients with diabetes for an extended time interval and the potency of detecting hyperglycemia using CGM data as a reference. Methods: Thirty-eight inpatients with diabetes undergoing CGM were enrolled. MIET comprised a pretreatment step using a plastic microneedle array and glucose accumulation step with a hydrogel patch, which was placed on two sites from 9:00 AM to 5:00 PM or from 10:00 PM to 6:00 AM. IG AUC was calculated by accumulated glucose extracted by hydrogel patches using sodium ion as standard. Results: A significant correlation was observed between the predicted AUC by MIET and CGM in daytime (r=0.76) and nighttime (r=0.82). The optimal cutoff for the IG AUC value of MIET to predict hyperglycemia over 200 mg/dL measured by CGM for 8 hours was 1,067.3 mg·hr/dL with 88.2% sensitivity and 81.5% specificity. Conclusion: We showed that 8-hour IG AUC levels using MIET were valuable in estimating the blood glucose AUC without blood sampling. The results also supported the concept of using this technique for evaluating glucose excursion and for screening hyperglycemia during 8 hours in patients with diabetes at any time of day.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
American Diabetes Association / 2016 / 5. Glycemic targets / Diabetes Care 39(Suppl 1):S39~46
Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus / 2010 / Report of the committee on the classification and diagnostic criteria of diabetes mellitus / J Diabetes Investig 1:212~228
Diabetes Control and Complications Trial Research Group / 1993 / The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus / N Engl J Med 329:977~986
Ohkubo Y / 1995 / Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study / Diabetes Res Clin Pract 28:103~117
DECODE Study Group, European Diabetes Epidemiology Group / 2003 / Is the current definition for diabetes relevant to mortality risk from all causes and cardiovascular and noncardiovas cular diseases? / Diabetes Care 26:688~696
Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus / 2010 / Report of the committee on the classification and diagnostic criteria of diabetes mellitus / J Diabetes Investig 1:212~228
Diabetes Control and Complications Trial Research Group / 1993 / The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus / N Engl J Med 329:977~986
Ohkubo Y / 1995 / Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study / Diabetes Res Clin Pract 28:103~117
DECODE Study Group, European Diabetes Epidemiology Group / 2003 / Is the current definition for diabetes relevant to mortality risk from all causes and cardiovascular and noncardiovas cular diseases? / Diabetes Care 26:688~696
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