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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 74 - 81 (8page)
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Background: Metabolic syndrome (MetS) is a complex and multifactorial disorder characterized by insulin resistance, dyslipidaemia, hyperglycemia, abdominal obesity, and elevated blood pressure. The apolipoprotein A5 (APOA5) gene variants have been reported to correlate with two major components of MetS, including low levels of high density lipoprotein cholesterol (HDL-C) and high levels of triglyceride. In the present study, we explored the associations between five single nucleotide polymorphisms (SNPs) of APOA5 gene and the MetS risk. Methods: In a case-control design, 120 Iranian children and adolescents with/without MetS were genotyped by polymerase chain reaction-sequencing for these SNPs. Then, we investigated the association of SNPs, individually or in haplotype constructs, with MetS risk. Results: The rs34089864 variant and H1 haplotype (harboring the two major alleles of rs619054 and rs34089864) were associated with HDL-C levels. However, there was no significant association between different haplotypes/individual SNPs and MetS risk. Conclusion: These results presented no association of APOA5 3’UTR SNPs with MetS. Further studies, including other polymorphisms, are required to investigate the involvement of APOA5 gene in the genetic susceptibility to MetS in the pediatric age group.
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참고문헌 (29)
참고문헌 신청
Pollex RL / 2006 / Genetic determinants of the metabolic syndrome / Nat Clin Pract Cardiovasc Med 3:482~489
Roche HM / 2005 / The metabolic syndrome: the crossroads of diet and genetics / Proc Nutr Soc 64:371~377
Chien KL / 2009 / Association between sequence variant of c.553 G > T in the apolipoprotein A5 gene and metabolic syndrome, insulin resistance, and carotid atherosclerosis / Transl Res 154:133~141
Nilsson SK / 2011 / Apolipoprotein A-V: a potent triglyceride reducer / Atherosclerosis 219:15~21
Zhang Z / 2011 / Apolipoprotein A5 polymorphisms and risk of coronary artery disease: a meta-analysis / Biosci Trends 5:165~172
Roche HM / 2005 / The metabolic syndrome: the crossroads of diet and genetics / Proc Nutr Soc 64:371~377
Chien KL / 2009 / Association between sequence variant of c.553 G > T in the apolipoprotein A5 gene and metabolic syndrome, insulin resistance, and carotid atherosclerosis / Transl Res 154:133~141
Nilsson SK / 2011 / Apolipoprotein A-V: a potent triglyceride reducer / Atherosclerosis 219:15~21
Zhang Z / 2011 / Apolipoprotein A5 polymorphisms and risk of coronary artery disease: a meta-analysis / Biosci Trends 5:165~172
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