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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 384 - 400 (17page)
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초록· 키워드
오류제보하기
Although testosterone therapy in men with testosterone deficiency was introduced in the early 1940s, utilization of this effective treatment approach in hypogonadal men is met with considerable skepticism and resistance. Indeed, for decades, the fear that testosterone may cause prostate cancer has hampered clinical progress in this field. Nevertheless, even after considerable knowledge was acquired that this fear is unsubstantiated, many in the medical community remain hesitant to utilize this therapeutic approach to treat men with hypogonadism. As the fears concerning prostate cancer have subsided, a new controversy regarding use of testosterone therapy and increase in cardiovascular disease was introduced. Although the new controversy was based on one ill-fated clinical trial, one meta-analysis with studies that utilized unapproved formulation in men with liver cirrhosis, and two retrospective studies with suspect or nonvalidated statistical methodologies and database contaminations, the flames of such controversy were fanned by the lay press and academics alike. In this review we discuss the adverse effect of testosterone deficiency and highlight the numerous proven benefits of testosterone therapy on men's health and debunk the myth that testosterone therapy increases cardiovascular risk. Ultimately, we believe that there is considerable scientific and clinical evidence to suggest that testosterone therapy is safe and effective with restoration of physiological levels in men with testosterone deficiency, irrespective of its etiology.
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등록된 정보가 없습니다.
참고문헌 (100)
참고문헌 신청
Morgentaler A / 2015 / Testosterone therapy and cardiovascular risk: advances and controversies / Mayo Clin Proc 90:224~251
Morgentaler A / 2016 / International expert consensus conference on testosterone deficiency and its treatment- resolutions and conclusions / Mayo Clin Proc 91:881~896
Snyder PJ / 2016 / Effects of testosterone treatment in older men / N Engl J Med 374:611~624
Traish AM / 2014 / Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study / Int J Clin Pract 68:314~329
Traish AM / 2016 / Testosterone therapy in men with testosterone deficiency: are the benefits and cardiovascular risks real or imagined? / Am J Physiol Regul Integr Comp Physiol 311:R566~R573
Morgentaler A / 2016 / International expert consensus conference on testosterone deficiency and its treatment- resolutions and conclusions / Mayo Clin Proc 91:881~896
Snyder PJ / 2016 / Effects of testosterone treatment in older men / N Engl J Med 374:611~624
Traish AM / 2014 / Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study / Int J Clin Pract 68:314~329
Traish AM / 2016 / Testosterone therapy in men with testosterone deficiency: are the benefits and cardiovascular risks real or imagined? / Am J Physiol Regul Integr Comp Physiol 311:R566~R573
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Comparison of Serum Cortisol and Testosterone Levels in Acute and Chronic Central Serous Chorioretinopathy
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Effects of Veratrum maackii extract on testosterone-induced benign prostatic hyperplasia in rats
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Optimization of Benign Brostatic Hyperplasia (BPH) model in wister rat
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