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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 423 - 428 (6page)
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Purpose: To evaluate the impact that the 2012 US Preventive Services Task Force (USPSTF) prostate-specific antigen (PSA) screening guidelines have had on the diagnosis of prostate cancer, we compared the incidence and distribution of new cases diagnosed in 2011-before the USPSTF PSA screening recommendations versus 2014 at which time the guidelines were widely adopted. Materials and Methods: We identified all prostate biopsies performed by a large urology group practice utilizing a centralized pathology lab. We examined total biopsies performed, percentage of positive biopsies, and for those with positive biopsies examined for differences in patient age, PSA, and Gleason score. Results: A total of 4,178 biopsies were identified – 2,513 in 2011 and 1,665 in 2014. The percentage of positive biopsies was 27% in 2011 versus 34% in 2014 (p<0.0001). Among patients with positive biopsies, we found statistically significant differences between the 2 cohorts in the median ages and Gleason scores. Patients were about 1 year younger in 2014 compared to 2011 (t-test; p=0.043). High Gleason scores (8–10) were diagnosed in 19% of the 2014 positive biopsies versus 9% in the 2011 positive biopsies (chi square; p<0.0001). Conclusions: After the widespread implementation of the 2011 USPTF PSA screening guidelines, 34% fewer biopsies were performed with a 29% increase in positive biopsy rates. We found a significantly higher incidence of high grade disease in 2014 compared with 2011. The percentage of patients with positive biopsies having Gleason scores 8–10 more than doubled in 2014. The higher incidence of these more aggressive cancers must be part of the discussion regarding PSA screening.
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참고문헌 (26)
참고문헌 신청
Andriole GL / 2012 / Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial:mortality results after 13 years of follow-up / J Natl Cancer Inst 104:125~132
Schröder FH / 2009 / Screening and prostate-cancer mortality in a randomized European study / N Engl J Med 360:1320~1328
Penson DF / 2015 / The pendulum of prostate cancer screening / JAMA 314:2031~2033
Moyer VA / 2012 / Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement / Ann Intern Med 157:120~134
Carlsson S / 2012 / Prostate cancer screening: facts, statistics, and interpretation in response to the US Preventive Services Task Force Review / J Clin Oncol 30:2581~2584
Schröder FH / 2009 / Screening and prostate-cancer mortality in a randomized European study / N Engl J Med 360:1320~1328
Penson DF / 2015 / The pendulum of prostate cancer screening / JAMA 314:2031~2033
Moyer VA / 2012 / Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement / Ann Intern Med 157:120~134
Carlsson S / 2012 / Prostate cancer screening: facts, statistics, and interpretation in response to the US Preventive Services Task Force Review / J Clin Oncol 30:2581~2584
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