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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 384 - 392 (9page)
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초록· 키워드
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Background: A very low protein diet (VLPD) with ketoacid analogs of essential amino acids (KA/EAA) administration can remarkably influence protein synthesis and metabolic disturbances of patients with advanced chronic kidney disease (CKD), and may also slow the decline in renal function. Methods: A retrospective cohort study was carried out to monitor renal progression and metabolic and nutritional status among 140 patients with CKD stage III or IV. One group (n = 70) was on a low protein diet (LPD) with 0.6 g of protein intake, and another group (n = 70) was on a VLPD with 0.3 g of protein and KA/EAA supplementation of 100 mg/kg/day for 12 months. Results: At 12-month follow-up, estimated glomerular filtration rate (GFR) significantly decreased from 41.6 ± 10.2 to 36.4 ± 8.8 mL/min/1.73 m2 (P < 0.001) and urine protein increased from 0.6 ± 0.5 to 0.9 ± 1.1 g/day (P = 0.017) in the LPD group, but no significant changes in estimated GFR and urine protein were found in the VLPD plus KA/ EAA group. A significant mean difference in rate of change in estimated GFR (-5.2 ± 3.6 mL/min/1.73 m2 per year; P < 0.001) was observed between the two groups. After Cox regression analysis, treatment with VLPD plus KA/EAA significantly protected against the incidence of declining GFR > 10% annually (adjusted hazard ratio, 0.42; 95% confidence interval, 0.23-0.79; P = 0.006) and significant correlations were found between using VLPD plus KA/EEA and increased GFR. Conclusion: VLPD supplementation with KA/EAA is associated with delayed renal progression while preserving the nutritional status in the patients with CKD. Co-administration of VLPD and KA/EAA may prove an effective alternative to conservative management of CKD.
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참고문헌 (29)
참고문헌 신청
Walser M / 1993 / Does prolonged protein restriction preceding dialysis lead to protein malnutrition at the onset of dialysis? / Kidney Int 44:1139~1144
Feiten SF / 2005 / Short-term effects of a very-low-protein diet supplemented with ketoacids in nondialyzed chronic kidney disease patients / Eur J Clin Nutr 59:129~136
Gao X / 2011 / Low-protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: a role for KLF15 / Kidney Int 79:987~996
Brodsky IG / 1992 / Effects of low-protein diets on protein metabolism in insulin-dependent diabetes mellitus patients with early nephropathy / J Clin Endocrinol Metab 75:351~357
Yang X / 2015 / Effects of low-protein diets supplemented with ketoacid on expression of TGF-b and its receptors in diabetic rats / Biomed Res Int 2015:873519
Feiten SF / 2005 / Short-term effects of a very-low-protein diet supplemented with ketoacids in nondialyzed chronic kidney disease patients / Eur J Clin Nutr 59:129~136
Gao X / 2011 / Low-protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: a role for KLF15 / Kidney Int 79:987~996
Brodsky IG / 1992 / Effects of low-protein diets on protein metabolism in insulin-dependent diabetes mellitus patients with early nephropathy / J Clin Endocrinol Metab 75:351~357
Yang X / 2015 / Effects of low-protein diets supplemented with ketoacid on expression of TGF-b and its receptors in diabetic rats / Biomed Res Int 2015:873519
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