지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,127 - 1,145 (19page)
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초록· 키워드
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Several theories have been proposed to explain the etiology of adolescent idiopathic scoliosis (AIS) until present. However, limited data are available regarding the impact of vitamin D insufficiency or deficiency on scoliosis. Previous studies have shown that vitamin D deficiency and insufficiency are prevalent in adolescents, including AIS patients. A series of studies conducted in Hong Kong have shown that as many as 30% of these patients have osteopenia. The 25-hydroxyvitamin D3 level has been found to positively correlate with bone mineral density (BMD) in healthy adolescents and negatively with Cobb angle in AIS patients; therefore, vitamin D deficiency is believed to play a role in AIS pathogenesis. This study attempts to review the relevant literature on AIS etiology to examine the association of vitamin D and various current theories. Our review suggested that vitamin D deficiency is associated with several current etiological theories of AIS. We postulate that vitamin D deficiency and/or insufficiency affects AIS development by its effect on the regulation of fibrosis, postural control, and BMD. Subclinical deficiency of vitamin K2, a fat-soluble vitamin, is also prevalent in adolescents; therefore, it is possible that the high prevalence of vitamin D deficiency is related to decreased fat intake. Further studies are required to elucidate the possible role of vitamin D in the pathogenesis and clinical management of AIS.
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등록된 정보가 없습니다.
참고문헌 (187)
참고문헌 신청
Konieczny MR / 2013 / Epidemiology of adolescent idiopathic scoliosis / J Child Orthop 7:3~9
Burwell RG / 2008 / Concepts on the pathogenesis of adolescent idiopathic scoliosis: bone growth and mass, vertebral column, spinal cord, brain, skull, extra-spinal left-right skeletal length asymmetries, disproportions and molecular pathogenesis / Stud Health Technol Inform 135:3~52
Cheng JC / 1999 / Persistent osteopenia in adolescent idiopathic scoliosis : a longitudinal follow up study / Spine(Phila Pa 1976) 24:1218~1222
Lee WT / 2005 / Association of osteopenia with curve severity in adolescent idiopathic scoliosis : a study of 919 girls / Osteoporos Int 16:1924~1932
Hung VW / 2005 / Osteopenia : a new prognostic factor of curve progression in adolescent idiopathic scoliosis / J Bone Joint Surg Am 87:2709~2716
Burwell RG / 2008 / Concepts on the pathogenesis of adolescent idiopathic scoliosis: bone growth and mass, vertebral column, spinal cord, brain, skull, extra-spinal left-right skeletal length asymmetries, disproportions and molecular pathogenesis / Stud Health Technol Inform 135:3~52
Cheng JC / 1999 / Persistent osteopenia in adolescent idiopathic scoliosis : a longitudinal follow up study / Spine(Phila Pa 1976) 24:1218~1222
Lee WT / 2005 / Association of osteopenia with curve severity in adolescent idiopathic scoliosis : a study of 919 girls / Osteoporos Int 16:1924~1932
Hung VW / 2005 / Osteopenia : a new prognostic factor of curve progression in adolescent idiopathic scoliosis / J Bone Joint Surg Am 87:2709~2716
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