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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 37 - 41 (5page)
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초록· 키워드
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Amyotrophic lateral sclerosis (ALS) patients rarely present with either syndrome of inappropriate antidiuretic hormone secretion or generalized edema. Tolvaptan is a selective vasopressin V2 receptor antagonist that produces effective aquaresis, and its use in ALS patients has not been previously reported. A 50-year-old male ALS patient was admitted because of both generalized edema and dilutional hyponatremia. These manifestations were refractory to conventional diuretics and fluid therapy, but a very brisk diuresis was induced by tolvaptan administration. Edema and hyponatremia were also improved, and the patient was able to be discharged without tolvaptan. In this case report, we postulate how edema and dilutional hyponatremia developed in the patient, and discuss the mechanism of tolvaptan in treating hypervolemic hyponatremia. Further experience is necessary to evaluate the usefulness of tolvaptan in patients with neurological disorders.
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참고문헌 (14)
참고문헌 신청
Miller RG / 2009 / Quality Standards Subcommittee of the American Academy of Neurology: Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology / Neurology 73:1227~1233
Jackson CE / 2015 / Symptom Management and End-of-Life Care in Amyotrophic Lateral Sclerosis / Neurol Clin 33:889~908
Oey PL / 2002 / Subtle involvement of the sympathetic nervous system in amyotrophic lateral sclerosis / Muscle Nerve 25:402~408
Yui Inoue / 2017 / Syndrome of inappropriate antidiuretic hormone secretion associated with amyotrophic lateral sclerosis in a patient developing carbon dioxide narcosis / Intern Med 56:797~803
Yoshida Y / 1999 / Syndrome of inappropriate secretion of antidiuretic hormone associated with amyotrophic lateral sclerosis in respiratory failure / Respirology 4:185~187
Jackson CE / 2015 / Symptom Management and End-of-Life Care in Amyotrophic Lateral Sclerosis / Neurol Clin 33:889~908
Oey PL / 2002 / Subtle involvement of the sympathetic nervous system in amyotrophic lateral sclerosis / Muscle Nerve 25:402~408
Yui Inoue / 2017 / Syndrome of inappropriate antidiuretic hormone secretion associated with amyotrophic lateral sclerosis in a patient developing carbon dioxide narcosis / Intern Med 56:797~803
Yoshida Y / 1999 / Syndrome of inappropriate secretion of antidiuretic hormone associated with amyotrophic lateral sclerosis in respiratory failure / Respirology 4:185~187
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