지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.22 No.3
- 발행연도
- 2016.1
- 수록면
- 444 - 451 (8page)
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초록· 키워드
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Background/AimsThe prevalence of gastroesophageal reflux disease (GERD) is high in patients with idiopathic pulmonary fibrosis (IPF). GERD may causechronic microaspiration that leads to repeated subclinical lung injury, which leads to pulmonary fibrosis. Although some studies havesuggested that proton pump inhibitors (PPI) were associated with a good prognosis in IPF, their effects remain unclear. MethodsWe retrospectively reviewed 786 consecutive adult patients with IPF at Seoul National University Bundang Hospital between April2003 and March 2015. ResultsMean duration of follow-up was 2.6 ± 2.8 years. Of the 786 patients with IPF, 107 (13.6%) were given diagnoses of GERD, and 103(13.1%) died due to IPF-related pneumonia or respiratory failure. The prevalence of GERD and the cumulative incidence of de novoGERD increased depending on the period of follow-up in patients with IPF. Patients administered PPI for more than four months hada lower IPF-related mortality rate than patients on PPI less than 4 months (Log-rank P -value = 0.024 in Kaplan-Meier curve). In aunivariate and multivariate Cox regression hazard model, younger age (hazard ratio [HR], 1.06; 95% CI, 1.03-1.10; P = 0.001), higherinitial forced vital capacity (HR, 0.98; 95% CI, 0.96-0.99; P = 0.004), and longer duration of PPI use (HR, 0.97; 95% CI, 0.95-1.00; P= 0.022), but not a diagnosis of GERD, were significantly associated with lower IPF-related mortality. ConclusionsIn Korean patients with IPF, the prevalence of GERD was lower than in other countries. PPI use for at least 4 months may have aprotective effect against IPF-related mortality.
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참고문헌 (29)
참고문헌 신청
el-Serag HB / 1997 / Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans / Gastroenterology 113:755~760
Galmiche JP / 2008 / Review article: respiratory manifestations of gastro-oesophageal reflux disease / Aliment Pharmacol Ther 27:449~464
Richter JE / 2005 / Review article: extraoesophageal manifestations of gastrooesophageal reflux disease / Aliment Pharmacol Ther 22(suppl 1):70~80
Bandeira CD / 2009 / Prevalence of gastroesophageal reflux disease in patients with idiopathic pulmonary fibrosis / J Bras Pneumol 35:1182~1189
Basseri B / 2010 / Esophageal motor dysfunction and gastroesophageal reflux are prevalent in lung transplant candidates / Ann Thorac Surg 90:1630~1636
Galmiche JP / 2008 / Review article: respiratory manifestations of gastro-oesophageal reflux disease / Aliment Pharmacol Ther 27:449~464
Richter JE / 2005 / Review article: extraoesophageal manifestations of gastrooesophageal reflux disease / Aliment Pharmacol Ther 22(suppl 1):70~80
Bandeira CD / 2009 / Prevalence of gastroesophageal reflux disease in patients with idiopathic pulmonary fibrosis / J Bras Pneumol 35:1182~1189
Basseri B / 2010 / Esophageal motor dysfunction and gastroesophageal reflux are prevalent in lung transplant candidates / Ann Thorac Surg 90:1630~1636
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