지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.23 No.1
- 발행연도
- 2017.1
- 수록면
- 20 - 26 (7page)
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초록· 키워드
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Traditionally, irritable bowel syndrome (IBS) has not been regarded as an organic disease, and the pathophysiology of IBS is heterogeneous. Currently, the diagnosis of IBS is based upon the Rome diagnostic criteria. The performance of these criteria is only modest in predicting IBS, and moreover their validation is lacking. Additionally, as functional symptoms are common in the general population, healthy controls or volunteers are difficult to define and there is currently no definition of “normal” in the Rome criteria. Due to the weaknesses of the current diagnostic criteria, patients and doctors expect new gold standard diagnostic tools. Various etiologic mechanisms result in potential biomarkers. The focus of this research has been to find non-invasive biomarkers from serum, breath gas, and fecal materials. Though biomarkers should be based on biological and pathogenic processes, most biomarkers for IBS have been developed to identify organic diseases and therefore eliminate IBS. To date, these types of biomarkers for IBS have been disappointing. The purposes of developing biomarkers include improvement of diagnosis, differentiation from other organic diseases, and discrimination of IBS subtypes. A true mechanistic biomarker would make it possible to rule in IBS, rather than to rule out other organic diseases. New serologic biomarkers for diarrhea-predominant IBS have been introduced based on the pathophysiologic findings from a rat model and validation in a large-scale clinical trial. Further investigations of abnormal organic findings from each subtype of IBS would enable the development of new, simple subtype-specific biomarkers.
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참고문헌 (46)
참고문헌 신청
Mearin F / 2016 / Bowel Disorders / Gastroenterology 150:1393~1407
Engsbro AL / 2013 / Patients suspected of irritable bowel syndrome--cross-sectional study exploring the sensitivity of Rome III criteria in primary care / Am J Gastroenterol 108:972~980
Ford AC / 2013 / Validation of the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care / Gastroenterology 145:1262~1270.e1
Stanisic V / 2014 / The overlap between IBS and IBD: what is it and what does it mean? / Expert Rev Gastroenterol Hepatol 8:139~145
Ghorbani S / 2015 / Healthy control subjects are poorly defined in case-control studies of irritable bowel syndrome / Ann Gastroenterol 28:87~93
Engsbro AL / 2013 / Patients suspected of irritable bowel syndrome--cross-sectional study exploring the sensitivity of Rome III criteria in primary care / Am J Gastroenterol 108:972~980
Ford AC / 2013 / Validation of the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care / Gastroenterology 145:1262~1270.e1
Stanisic V / 2014 / The overlap between IBS and IBD: what is it and what does it mean? / Expert Rev Gastroenterol Hepatol 8:139~145
Ghorbani S / 2015 / Healthy control subjects are poorly defined in case-control studies of irritable bowel syndrome / Ann Gastroenterol 28:87~93
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