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학술저널
저자정보
Oana Belei (First Pediatric Clinic University of Medicine and Pharmacy Victor Babes Timisoara Roman) Laura Olariu (First Pediatric Clinic University of Medicine and Pharmacy Victor Babes Timisoara Roman) Andreea Dobrescu (Genetics Department University of Medicine and Pharmacy Victor Babes Timisoara Romania) Tamara Marcovici (First Pediatric Clinic University of Medicine and Pharmacy Victor Babes Timisoara Roman) Otilia Marginean (First Pediatric Clinic University of Medicine and Pharmacy Victor Babes Timisoara Roman)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.1
발행연도
2018.1
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51 - 57 (7page)

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Background/Aims Gastroesophageal reflux disease (GERD) is a frequent condition diagnosed in children and treated with proton pump inhibitors (PPI). Long-term PPI administration can alter intestinal bacterial population by suppressing the gastric acid barrier and may cause diarrhea. The aim of this study is to evaluate the prevalence of small intestinal bacterial overgrowth assessed by glucose hydrogen breath test among children that received 12 weeks of PPI with or without probiotics (Lactobacillus reuteri DSM 17938) associated, compared to controls. Methods Glucose hydrogen breath test was performed before PPI treatment and after 12 weeks of PPI treatment to 128 consecutive children with GERD (1–18 years old) and a control group (120 healthy children). The children with GERD were randomized into 2 groups: placebo group (64 who received PPI and placebo for 12 weeks) and probiotics group (64 who received PPI and probiotics for 12 weeks). Results After 12 weeks of treatment, dysbiosis was detected among 56.2% of children from placebo group (36/64), compared to 6.2% of children from the probiotics group (4/64, P < 0.001). Bacterial overgrowth was detected in 5% of controls (6/120). Probiotics group had a lower prevalence of dysbiosis, similar to controls (P = 0.740). Conclusion Probiotics administration decreased the rate of dysbiosis among children treated with PPI.

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