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논문 기본 정보

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학술저널
저자정보
Alaa A. Elzarkaa (Department of Obstetrics and Gynecology University of Alexandria Alexandria Egypt) Waleed Shaalan (Department of Obstetrics and Gynecology University of Alexandria Alexandria Egypt) Doaa Elemam (Department of Public Health and Preventive Medicine University of Mansura Mansura Egypt) Hassan Mansour (Department of Obstetrics and Gynecology University of Alexandria Alexandria Egypt) Mahmoud Melis (Department of Obstetrics and Gynecology University of Alexandria Alexandria Egypt) Eduard Malik (Department of Obstetrics and Gynecology University Women's Hospital Klinikum Oldenburg University o) Amr A. Soliman (Department of Obstetrics and Gynecology University Women's Hospital Klinikum Oldenburg University o)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.29 No.4
발행연도
2018.1
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1 - 10 (10page)

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OBJECTIVE: A numerical score, the peritoneal cancer index (PCI), was developed to reflect the extent of tumor growth in gastric and colorectal cancers and to tailor treatment. This study aimed to examine the value of the PCI score in advanced epithelial ovarian cancer (EOC) regarding completeness of surgical cytoreduction and survival. METHODS: This was a prospective observational cohort study. Patients with primary serous EOC at International Federation of Gynecology and Obstetrics (FIGO) stages IIIB or higher were included. Patients with FIGO stage IVB as well as those assigned to receive neoadjuvant treatment were excluded from the study. The PCI was obtained and registered intraoperatively. RESULTS: In the study period we recruited 96 patients with serous EOC stage IIIB-IVA. A PCI score cut-off value of 13 was calculated using a receiver operator characteristic (ROC) curve, above which worse survival is expected (area under the curve [AUC]=0.641; 95% confidence interval [CI]=0.517-0.765; sensitivity and specificity 80.6%, 45.0%, respectively; p=0.050). A multivariate analysis determined that suboptimal surgical cytoreduction was the only independent predictive factor for recurrence (odds ratio [OR]=7.548; 95% CI=1.473-38.675; p=0.015). A multivariate analysis determined that only suboptimal surgical cytoreduction (hazard ratio [HR]=2.33; 95% CI=0.616-8.795; p=0.005), but not PCI score >13 (HR=1.289; 95% CI=0.329-5.046; p=0.716), was an independent predictive factor for death. CONCLUSION: We conclude from this study that the PCI score is a reliable tool helping to assess the extent of disease in advanced serous EOC patients and may help predicting complete surgical cytoreduction but cannot qualify as a predictor of survival.

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참고문헌 (32)

참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108 Crossref Kaatsch P / 2013 / Krebs in Deutschland 2009/2010 / Robert Koch-Institut google schola American Cancer Society / 2007 / Global cancer facts & figures 2007 / American Cancer Society google schola Hoskins WJ / 1994 / The effect of diameter of largest residual disease on survival after primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma / Am J Obstet Gynecol 170:974~979 Crossref Trimbos JB / 2003 / Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma: European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm trial / J Natl Cancer Inst 95:113~125 Crossref

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