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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Several genetic and epigenetic theories have been suggested to explain the intricacies of life and death. However, several questions remain unsettled regarding cellular death events, particularly of living tissue in the case of cancer patients, such as the fate and adaptation of cancer cells after biological death. It is possible that cancer cells can display the intent to communicate with the external environment after biological death by means of molecular, genetic, and epigenetic pathways. Whether these cancer cells contain special information in the form of coding that may help them survive beyond the biological death of cancer patients is unknown. To understand these queries in the cancer field, we hypothesize the epigenomic hard drive (EHD) as a cellular component to record and store global epigenetic events in cancerous and non-cancerous tissues of cancer patients. This mini-review presents the novel concept of EHD that is reinforced with the existing knowledge of genetic and epigenetic events in cancer. Further, we summarize the EHD understanding that may impart much potential and interest for basic and clinical scientists to unravel mechanisms of carcinogenesis, therapeutic markers, and differential drug responses.
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참고문헌 (32)
참고문헌 신청
Pattabiraman DR / 2014 / Tackling the cancer stem cells:what challenges do they pose? / Nat Rev Drug Discov 13:497~512
Fuchs Y / 2015 / Live to die another way: modes of programmed cell death and the signals emanating from dying cells / Nat Rev Mol Cell Biol 16:329~344
Feinberg AP / 2016 / Epigenetic modulators, modifiers and mediators in cancer aetiology and progression / Nat Rev Genet 17:284~299
Moran S / 2016 / Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis / Lancet Oncol 17:1386~1395
Torres CM / 2016 / The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity / Science 353:aaf1644
Fuchs Y / 2015 / Live to die another way: modes of programmed cell death and the signals emanating from dying cells / Nat Rev Mol Cell Biol 16:329~344
Feinberg AP / 2016 / Epigenetic modulators, modifiers and mediators in cancer aetiology and progression / Nat Rev Genet 17:284~299
Moran S / 2016 / Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis / Lancet Oncol 17:1386~1395
Torres CM / 2016 / The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity / Science 353:aaf1644
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