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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 109 - 115 (7page)
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This paper presents a proof-of-concept microfluidic aptamer-based sensor for thrombin pointof- care testing using electrochemical impedance spectroscopy. The disposable biosensor is composed of a polydimethylsiloxane (PDMS) channel layer over a glass substrate. The substrate surface has an Au working electrode and a Pt reference/counter electrode. In this study, human thrombin was used as a biomarker for disease diagnosis. An unlabeled aptamer specific to thrombin was immobilized on a working electrode and electrochemical impedance was measured as thrombin was injected into the biosensor. Thrombin was detected by measuring change in impedance. The proposed biochip had a detection range of 0.1-100,000 ng mL-1 for thrombin concentration and a limit of detection of 0.1 ng mL-1. The results indicated that our biochip could be an effective tool for other molecular diagnostic systems.
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참고문헌 (30)
참고문헌 신청
Crean, S. M. / 2008 / Exogenous bovine thrombin as a biomarker of exposure and outcome / Expert Rev. Mol. Diagn. 8:651~661
Kricka, L.J. / 2002 / Prospect for microbiochips in immunoassays and immunoassay test at the point-of-care / J. Clin. Ligand Assay 25:317~324
Ko, Y.J. / 2008 / Real-time immunoassay with a PDMSglass hybrid microfilter electro-immunosensing chip using nanogold particles and silver enhancement / Sens. Actuator B-Chem. 132:327~333
Deng, B. / 2014 / Aptamer binding assays for proteins:The thrombin example-A review / Anal. Chim. Acta 837:1~15
Citartan, M. / 2012 / Assay for aptamer-based platforms / Biosens. Bioelectron. 34:1~11
Kricka, L.J. / 2002 / Prospect for microbiochips in immunoassays and immunoassay test at the point-of-care / J. Clin. Ligand Assay 25:317~324
Ko, Y.J. / 2008 / Real-time immunoassay with a PDMSglass hybrid microfilter electro-immunosensing chip using nanogold particles and silver enhancement / Sens. Actuator B-Chem. 132:327~333
Deng, B. / 2014 / Aptamer binding assays for proteins:The thrombin example-A review / Anal. Chim. Acta 837:1~15
Citartan, M. / 2012 / Assay for aptamer-based platforms / Biosens. Bioelectron. 34:1~11
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