지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 314 - 321 (8page)
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초록· 키워드
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Background/Aims: Peyer’s patches (PPs) are aggregates of lymphoid follicles that are mainly located in the distal ileum; theyplay a major role in mucosal immunity. We recently reported that patients with ulcerative colitis (UC) have alterations in PPsthat can be detected using narrow-band imaging with magnifying endoscopy (NBI-ME). However, the usefulness of NBI-ME inUC treatment as a whole is still unknown. Methods: We collected NBI-ME images of PPs from 67 UC patients who had undergoneileocolonoscopy. We evaluated changes in the villi using the “villi index,” which is based on three categories: irregular formation,hyperemia, and altered vascular network pattern. The patients were divided into two groups on the basis of villi index:low (L)- and high (H)-types. We then determined the correlation between morphological alteration of the PPs and various clinicalcharacteristics. In 52 patients who were in clinical remission, we also analyzed the correlation between NBI-ME findings ofPPs and clinical recurrence. Results: The time to clinical recurrence was significantly shorter in remissive UC patients with HtypePPs than in those with L-type PPs (P <0.01). Moreover, PP alterations were not correlated with age, sex, disease duration,clinical activity, endoscopic score, or extent of disease involvement. Multivariate analysis revealed that the existence of H-typePPs was an independent risk factor for clinical recurrence (hazard ratio, 3.3; P <0.01). Conclusions: UC patients with morphologicalalterations in PPs were at high risk of clinical relapse. Therefore, to predict the clinical course of UC, it may be useful toevaluate NBI-ME images of PPs.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Iijima H / 2001 / Mucosal immune network in the gut for the control of infectious diseases / Rev Med Virol 11:117~133
Van Kruiningen HJ / 2002 / Distribution of Peyer’s patches in the distal ileum / Inflamm Bowel Dis 8:180~185
Leone V / 2013 / Diet, microbes, and host genetics:the perfect storm in inflammatory bowel diseases / J Gastroenterol 48:315~321
MacDonald TT / 1987 / Selective biopsy of human Peyer’s patches during ileal endoscopy / Gastroenterology 93:1356~1362
Annese V / 2013 / European evidence basedconsensus for endoscopy in inflammatory bowel disease / J Crohns Colitis 7:982~1018
Van Kruiningen HJ / 2002 / Distribution of Peyer’s patches in the distal ileum / Inflamm Bowel Dis 8:180~185
Leone V / 2013 / Diet, microbes, and host genetics:the perfect storm in inflammatory bowel diseases / J Gastroenterol 48:315~321
MacDonald TT / 1987 / Selective biopsy of human Peyer’s patches during ileal endoscopy / Gastroenterology 93:1356~1362
Annese V / 2013 / European evidence basedconsensus for endoscopy in inflammatory bowel disease / J Crohns Colitis 7:982~1018
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