지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 55 - 61 (7page)
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초록· 키워드
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Background/Aims: The therapeutic goal for treating ulcerative colitis (UC) patients has shifted to achieving mucosal healingover the past few years. However, at present, limited data is available on the correlation between endoscopic findings andhistological remission in patients with endoscopic mucosal healing. Methods: This was a prospective observational study conducted over a period of 18 months (January 2014 to June 2015) at Dayanand Medical College and Hospital, Ludhiana, Punjab,India. Patients diagnosed with UC who had been in clinical remission (n=76) for at least 6 months were evaluated for endoscopicremission. Those in endoscopic remission (Mayo score ≤1; 46/76, 60.5%) were subjected to multiple biopsies from therectosigmoid region and histological remission, which was then defined as grade 0/1 as per the Geboes criteria. Results: Of the46 patients in endoscopic remission (age, 18−73 years; male:female=1.5:1.0), majority had E1 (proctitis) disease (21/46, 45.6%)followed by E2 (left sided colitis) (18/46, 39.1%) and E3 disease (pancolitis) (7/46, 15.2%) at baseline. Histological remissionwas noted in 67.3% (31/46) of the patients, while 32.7% (15/46) still retained the histologically active disease in the form of infiltration of the lamina propria by eosinophils and neutrophils (13/15, 86.6%), cryptitis (14/15, 93.3%), and crypt abscesses (8/15,53.3%). On follow-up, after 1 year, 87.1% (27/31) of the patients who had been in histological remission remained clinically asymptomatic, while 12.9% (4/31) had relapsed. Among the 15 histologically active patients, 46.6% (7/15) remained in clinicalremission, while 53.3% (8/15) had relapsed. Conclusions: Histological remission, rather than endoscopic remission, predictsa sustained clinical remission and allows monitoring of therapy for the subsequent disease course in patients with UC.
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등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
D'Haens G / 2007 / A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis / Gastroenterology 132:763~786
Travis SP / 2011 / Review article: defining remission in ulcerative colitis / Aliment Pharmacol Ther 34:113~124
Geboes K / 2000 / A reproducible grading scale for histological assessment of inflammation in ulcerative colitis / Gut 47:404~409
Bryant RV / 2016 / Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up / Gut 65:408~414
Riley SA / 1991 / Microscopic activity in ulcerative colitis: what does it mean? / Gut 32:174~178
Travis SP / 2011 / Review article: defining remission in ulcerative colitis / Aliment Pharmacol Ther 34:113~124
Geboes K / 2000 / A reproducible grading scale for histological assessment of inflammation in ulcerative colitis / Gut 47:404~409
Bryant RV / 2016 / Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up / Gut 65:408~414
Riley SA / 1991 / Microscopic activity in ulcerative colitis: what does it mean? / Gut 32:174~178
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