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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 327 - 337 (11page)
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초록· 키워드
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Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing to colorectal carcinogenesis. However, recent evidences demonstrate that there are interactions between these 2 mechanisms. Genetic mutations enable disruption of epigenetic controls while epigenetic modifications can initiate genomic instability and carcinogenesis. This review summarized genetic mutations and epigenetic modifications in colorectal carcinogenesis and molecular classification of CRC subtype based on genetic or epigenetic biomarkers for treatment response and prognosis. Molecular subtypes of CRC will permit the implementation of precision medicine with better outcome of management for CRC.
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참고문헌 (62)
참고문헌 신청
Arnold M / 2017 / Global patterns and trends in colorectal cancer incidence and mortality / Gut 66:683~691
Lynch HT / 2003 / Hereditary colorectal cancer / N Engl J Med 348:919~932
Coppede F / 2014 / Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer / World J Gastroenterol 20:943~956
You JS / 2012 / Cancer genetics and epigenetics: two sides of the same coin? / Cancer Cell 22:9~20
Rao CV / 2013 / Genomic instability and colon carcinogenesis: from the perspective of genes / Front Oncol 3:130
Lynch HT / 2003 / Hereditary colorectal cancer / N Engl J Med 348:919~932
Coppede F / 2014 / Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer / World J Gastroenterol 20:943~956
You JS / 2012 / Cancer genetics and epigenetics: two sides of the same coin? / Cancer Cell 22:9~20
Rao CV / 2013 / Genomic instability and colon carcinogenesis: from the perspective of genes / Front Oncol 3:130
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