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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 538 - 546 (9page)
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Articular cartilage has limited regeneration capacity, thus significant challenge has been made to restore the functions. The development of hydrogels that can encapsulate and multiply cells, and then effectively maintain the chondrocyte phenotype is a meaningful strategy to this cartilage repair. In this study, we prepared alginate-hyaluronic acid based hydrogel with type I collagen being incorporated, namely Alg-HA-Col composite hydrogel. The incorporation of Col enhanced the chemical interaction of molecules, and the thermal stability and dynamic mechanical properties of the resultant hydrogels. The primary chondrocytes isolated from rat cartilage were cultured within the composite hydrogel and the cell viability recorded revealed active proliferation over a period of 21 days. The mRNA levels of chondrocyte phenotypes, including SOX9, collagen type II, and aggrecan, were significantly up-regulated when the cells were cultured within the Alg-HA-Col gel than those cultured within the Alg-HA. Furthermore, the secretion of sulphated glycosaminoglycan, a cartilage-specific matrix molecule, was recorded higher in the collagen-added composite hydrogel. Although more in-depth studies are required such as the in vivo functions, the currently-prepared Alg-HA-Col composite hydrogel is considered to provide favorable 3-dimensional matrix conditions for the cultivation of chondrocytes. Moreover, the cell-cultured constructs may be useful for the cartilage repair and tissue engineering.
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참고문헌 (50)
참고문헌 신청
Cuevas P / 1988 / Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo / Biochem Biophys Res Commun 156:611~618
Brenner JM / 2013 / Development of large engineered cartilage constructs from a small population of cells / Biotechnol Prog 29:213~221
Lach M / 2014 / Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment / J Tissue Eng 5
진은선 / 2014 / Implantation of Adipose Tissue-derived Mesenchymal Stem Cells in Degenerative Intervertebral Disc of Rat: When is the Most Effective time During the Degeneration Period / 조직공학과 재생의학 11(3):195~202
Brittberg M / 1994 / Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation / N Engl J Med 331:889~895
Brenner JM / 2013 / Development of large engineered cartilage constructs from a small population of cells / Biotechnol Prog 29:213~221
Lach M / 2014 / Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment / J Tissue Eng 5
진은선 / 2014 / Implantation of Adipose Tissue-derived Mesenchymal Stem Cells in Degenerative Intervertebral Disc of Rat: When is the Most Effective time During the Degeneration Period / 조직공학과 재생의학 11(3):195~202
Brittberg M / 1994 / Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation / N Engl J Med 331:889~895
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