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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 171 - 178 (8page)
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Epimorphic regeneration in vertebrates involves the restoration of lost tissue or organs through the formation of a regeneration blastema and occurs through a complex interaction of a number of molecular signaling pathways. Of the many effectors of successful tail regeneration in the lizard Hemidactylus flaviviridis, one crucial pathway is the cyclooxygenase-2 (COX-2) mediated PGE2 signaling pathway. The current study was aimed at understanding whether COX-2 signaling plays any role in the expression of Wnt/b-Catenin signaling components during regenerative outgrowth in H. flaviviridis. Etoricoxib—selective inhibitor of the inducible isoform of COX-2—was administered to lizards orally. We tested the expression of b-Catenin during wound epidermis and blastema stages in the regenerating tail and found a reduction in its expression in response to drug treatment. Further, it was observed that the expression of canonical Wnt ligands was greatly altered due to COX-2 inhibition. Our results provide evidence of a cross-talk between the COX-2 induced PGE2 pathway and Wnt/b-Catenin signaling in the regenerating lizard tail. An understanding of the interaction among various signaling pathways will help elucidate the mechanism underlying epimorphosis in lizards, the only amniotes capable of appendage regeneration.
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참고문헌 (36)
참고문헌 신청
Wallace H / 1981 / Vertebrate limb regeneration / Wiley
Call MK / 2005 / Vertebrate limb regeneration / Adv Biochem Eng Biotechnol 93:67~81
Stoick-Cooper C / 2007 / Distinct Wnt signaling pathways have opposing roles in appendage regeneration / Development 134:479~489
Kumar A / 1994 / Influence of catecholamine and acetylcholine neurotransmitters on tail regeneration in gekkonid lizard Hemidactylus flaviviridis / Ind J Exp Biol 32:767~771
Pilo B / 1994 / Effect of EGF on progress of tail regeneration in the gekkonid lizard Hemidactylus flaviviridis / J Anim Morph Physiol 41:61~66
Call MK / 2005 / Vertebrate limb regeneration / Adv Biochem Eng Biotechnol 93:67~81
Stoick-Cooper C / 2007 / Distinct Wnt signaling pathways have opposing roles in appendage regeneration / Development 134:479~489
Kumar A / 1994 / Influence of catecholamine and acetylcholine neurotransmitters on tail regeneration in gekkonid lizard Hemidactylus flaviviridis / Ind J Exp Biol 32:767~771
Pilo B / 1994 / Effect of EGF on progress of tail regeneration in the gekkonid lizard Hemidactylus flaviviridis / J Anim Morph Physiol 41:61~66
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