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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 287 - 296 (10page)
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The platelet-rich plasma (PRP) and antimicrobial peptides neutrophil extract (AMP extract) were prepared from rabbit neutrophils as two autologous blood-derived preparations, which could be applied locally to enhance healing process of tissues. Both preparations were analyzed using the MALDI TOF method for accurate qualitative assay. Growth factors (PDGF and VEGF) and microbicidal protein were reported in PRP. In AMP extract a-defensins, namely; NP-1, -2, -3a, -3b, -4, and -5 and cathelicidins represented among other by 15-kDa antibacterial protein (p15s) were detected. In the second part of our study the influence of antimicrobial extract on macrophages in vitro was tested. Then, degranulation of neutrophils in vitro and generation of reactive intermediates by these cells under the influence of AMP extract were assessed. As estimated, the addition of AMP extract into cultures of macrophages decreased superoxide anion generation after 5 days of incubation. Furthermore, AMP extract inhibited degranulation and respiratory burst in neutrophils, therefore in this regard it suppress proinflammatory effect of two studied populations of leukocytes.
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참고문헌 (23)
참고문헌 신청
Jameson C / 2007 / Autologous platelet concentrate for the production of platelet gel / Labmedicine 38:39~42
Marx R / 2001 / Platelet-rich plasma (PRP): what is PRP and what is not PRP / Implant Dent 10:225~228
Anitua E / 2006 / Effectiveness of autologous reparation rich in growth factors for the treatment of chronic cutaneous ulcers / J Biomed Mater Res Part B Appl Biomater 84B:415~421
Li G-Y / 2013 / Efficacy of leukocyte-and platelet-rich plasma gel(L-PRP Gel)in treating osteomyelitis in a rabbit model / J Orthop Res 31:949~956
Agier J / 2015 / Cathelicidin impact on inflammatory cells / Centr Eur J Immunol 40:225~235
Marx R / 2001 / Platelet-rich plasma (PRP): what is PRP and what is not PRP / Implant Dent 10:225~228
Anitua E / 2006 / Effectiveness of autologous reparation rich in growth factors for the treatment of chronic cutaneous ulcers / J Biomed Mater Res Part B Appl Biomater 84B:415~421
Li G-Y / 2013 / Efficacy of leukocyte-and platelet-rich plasma gel(L-PRP Gel)in treating osteomyelitis in a rabbit model / J Orthop Res 31:949~956
Agier J / 2015 / Cathelicidin impact on inflammatory cells / Centr Eur J Immunol 40:225~235
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