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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 679 - 698 (20page)
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In almost all human tissues and organs, adult stem cells or tissue stem cells are present in a unique location, the so-called stem cell niche or its equivalent, continuously replenishing functional differentiated cells. Those endogenous stem cells can be expanded for cell therapeutics using ex vivo cell culture or recalled for tissue repair in situ through cell trafficking and homing. In the aging process, inefficiency in the endogenous stem cell–mediated healing mechanism can emerge from a variety of impairments that accumulate in the processes of stem cell self-renewal, function, differentiation capacity, and trafficking through cell autonomous intrinsic pathways (such as epigenetic alterations) or systemic extrinsic pathways. This review examines the homeostasis of endogenous stem cells, particularly bone marrow stem cells, and their dysregulation in disease and aging and discusses possible intervention strategies. Several systemic pro-aging and rejuvenating factors, recognized in heterochronic parabiosis or premature aging progeroid animal models, are reviewed as possible anti-aging pharmaceutical targets from the perspective of a healthy environment for endogenous stem cells. A variety of epigenetic modifications and chromosome architectures are reviewed as an intrinsic cellular pathway for aging and senescence. A gradual increase in inflammatory burden during aging is also reviewed. Finally, the tissue repair and anti-aging effects of Substance-P, a peptide stimulating stem cell trafficking from the bone marrow and modifying the inflammatory response, are discussed as a future anti-aging target.
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참고문헌 (9)
참고문헌 신청
임지원 / 2016 / Effect of Fibroblast Growth Factor-2 and Retinoic Acid on Lineage Commitment of Bone Marrow Mesenchymal Stem Cells / 조직공학과 재생의학 13(1):47~56
진임건 / 2016 / Effect of Mesenchymal Stem Cells and Platelet- Derived Growth Factor on the Healing of Radiation Induced Ulcer in Rats / 조직공학과 재생의학 13(1):78~90
허성우 / 2016 / Autologous Bone Marrow Mesenchymal Cell Induced Chondrogenesis for the Treatment of Osteoarthritis of Knee / 조직공학과 재생의학 13(2):200~209
Ing Loon Sean Chua / 2016 / Signaling of Extracellular Matrices for Tissue Regeneration and Therapeutics / 조직공학과 재생의학 13(1):1~12
Guang-Yin Shen / 2016 / Local Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Model / 조직공학과 재생의학 13(3):297~303
진임건 / 2016 / Effect of Mesenchymal Stem Cells and Platelet- Derived Growth Factor on the Healing of Radiation Induced Ulcer in Rats / 조직공학과 재생의학 13(1):78~90
허성우 / 2016 / Autologous Bone Marrow Mesenchymal Cell Induced Chondrogenesis for the Treatment of Osteoarthritis of Knee / 조직공학과 재생의학 13(2):200~209
Ing Loon Sean Chua / 2016 / Signaling of Extracellular Matrices for Tissue Regeneration and Therapeutics / 조직공학과 재생의학 13(1):1~12
Guang-Yin Shen / 2016 / Local Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Model / 조직공학과 재생의학 13(3):297~303
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