지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
There are increasing number of cases of serum amylase and lipase levels being examined as part of health screening, but the clinical significance of these amylase and lipase levels is unclear. When the clinicians encounter patients with elevated pancreatic enzymes, the most common causes such as acute pancreatitis, hepatic or renal dysfunction should be ruled out first by thorough history taking, physical examination, and laboratory tests. Further tests including abdominal ultrasonography or computed tomography, lipid profile, tumor marker, isoenzyme, and calculation of amylase-to-creatinine clearance ratio or polyethylene glycol precipitation test should be performed to exclude other causes. If the pancreatic enzymes are continuously elevated through repeated tests without any apparent etiology, the diagnosis is made with chronic non-pathological pancreatic hyperenzymemia (CNPH). Magnetic resonance cholangiopancreatography is very useful and important modality for the patients with CNPH but the clinical significance of magnetic resonance cholangiopancreatography with secretin stimulation is still unclear. They can be evaluated through endoscopic ultrasonography with preference but it is less suitable for follow-up. Individualized approaches should be made after considering the need for active treatment or periodic follow-up for the benign pancreatic diseases associated with CNPH. It is difficult to conclude until more long-term data are reported because there are only limited number of researches and consensus on the range of tests to be performed for diagnosis, clinical significance of benign findings and end of follow-up in patients with CNPH.
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등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
Frulloni L / 2005 / Pancreatic hyperenzymemia:clinical significance and diagnostic approach / JOP 6:536~551
Matteucci E / 2016 / Diabetes and pancreas: why so difficult? Potential mechanisms of elevated serum pancreatic enzymes / Curr Med Chem 23:290~302
Tietz NW / 1993 / Lipase in serum--the elusive enzyme: an overview / Clin Chem 39:746~756
Terada T / 1993 / Extrahepatic peribiliary glands express alpha-amylase isozymes, trypsin and pancreatic lipase: an immunohistochemical analysis / Hepatology 18:803~808
Collen MJ / 1990 / Serum amylase in patients with renal insufficiency and renal failure / Am J Gastroenterol 85:1377~1380
Matteucci E / 2016 / Diabetes and pancreas: why so difficult? Potential mechanisms of elevated serum pancreatic enzymes / Curr Med Chem 23:290~302
Tietz NW / 1993 / Lipase in serum--the elusive enzyme: an overview / Clin Chem 39:746~756
Terada T / 1993 / Extrahepatic peribiliary glands express alpha-amylase isozymes, trypsin and pancreatic lipase: an immunohistochemical analysis / Hepatology 18:803~808
Collen MJ / 1990 / Serum amylase in patients with renal insufficiency and renal failure / Am J Gastroenterol 85:1377~1380
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