메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
이민경 (동의대학교 대학원 보건의과학과 부교수) 김희진 (동의대학교 대학원 보건의과학과 석사과정) 박민경 (경운대학교 치위생학과 조교수)
저널정보
한국구강보건과학회 한국구강보건과학회지 한국구강보건과학회지 제6권 제2호
발행연도
2018.1
수록면
53 - 58 (6page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Green coffee bean (GCB) is a raw coffee bean that has not yet been roasted. Green coffee bean is the unroasted or immature robust coffee bean. It is mostly composed of Chlorogenic Acids (CGA), caffeine, trigonelline, and the diterpenes cafestol and kahweol. Chlorogenic Acids (CGA) have the anti-cancer effect of restraining free oxygen radicals. Even though experiments using Green Coffee Bean Exract (GCBE) have been done in various fields, experiments with regard to orofacial pain have been few. The aim of this study is to investigate whether administration of GCBE may be beneficial in pain modulation in inflammatory orofacial pain. We investigated by using GCBE in the development and modulation of orofacial pain in rats. Male, 7- to 8-week-old, Sprague-Dawley rats weighing 240-280g were used in this study. Experiments were carried out using a subcutaneous (SC) pain model caused by the injection of 5% formalin into the right vibrissa pad (SC, 50 μl). The amount of scratching or rubbing to the injection site was recorded for 9 consecutive 5-minute intervals following injection of formalin. The experimental subjects were separated into 5 groups (n=4); Naive, formalin( 5%), formalin after distilled water (vehicle), formalin after GCBE (p.o.,concentrations of 30,60mg/mL). The number of behavioral reactions of scratching the facial region proximal to the injection site was recorded for 9 consecutive 5-minute intervals following injection of the formalin. As a result, we found that oral administration of GCBE (p.o., concentrations of 30, 60 mg/mL) has an effect of relieving the formalin-induced orofacial pain. In particular, high concentrations (60 mg/mL) of GCBE substantially decrease the nociceptive behavior. These results mean that GCBE may affect the occurrence of orofacial pain and modulation. Therefore, Green coffee bean extract may be a potential therapeutic treatment for orofacial pain.

목차

등록된 정보가 없습니다.

참고문헌 (23)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0