지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 19 - 27 (9page)
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초록· 키워드
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Background: The objective of the study was to evaluate the predictive value of plasma D-dimer at admission after acute ischemic stroke, and to assess its effect on short-term functional outcome. Methods: Fasting plasma D-dimer was measured in 290 consecutive patients (61.7% men, mean age 67.0±12.3 years) within 3 days after the onset of acute ischemic stroke. The outcomes were measured at 3-months after stroke onset, by the modified Rankin Scale (mRS). Results: Atrial fibrillation, hypertension, diabetes and involvement of the insular cortex, the levels of serum high sensitive C-reactive protein and D-dimer, as well as incidence of women and age, were all significantly higher in the poor outcome group (P<0.05). After the adjustment of National Institutes of Health Stroke Scale (NIHSS) scores on admission, the plasma D-dimer levels positively correlated with mRS (Spearman partial rho=0.247, P<0.001). The cut-off value of D-dimer level for prediction of poor outcomes was 0.35 mg/L (sensitivity 0.70, specificity 0.63, area under the curve 0.71). Furthermore, two multivariated logistic regression analysis models were performed. One model excluded the NIHSS score as an independent variable, and demonstrated that D-dimer (odds ratio, 1.24 for every 1.0 mg/L, P<0.05) was independently associated with poor functional outcome. Conversely, the other model which included the NIHSS score, did not show any such association. Conclusions: Plasma D-dimer level is a useful marker for short-term outcomes in acute ischemic stroke, and may have a role in risk stratification for predicting a poor outcome.
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참고문헌 (28)
참고문헌 신청
김종성 / 2014 / Stroke Becomes the 3rd Important Cause of Death in Korea; Is It a Time to Toast? / 대한뇌졸중학회지 16(2):55~56
Howard G / 1986 / Community hospital-based stroke programs: North Carolina, Oregon, and New York. III. factors influencing survival after stroke: proportional hazards analysis of 4219 patients / Stroke 17:294~299
Vila N / 2000 / Proinflammatory cytokines and early neurological worsening in ischemic stroke / Stroke 31:2325~2329
Whiteley W / 2009 / Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin-6 / PLoS Med 6:e1000145
Tripodi A / 2011 / D-dimer testing in laboratory practice / Clin Chem 57:1256~1262
Howard G / 1986 / Community hospital-based stroke programs: North Carolina, Oregon, and New York. III. factors influencing survival after stroke: proportional hazards analysis of 4219 patients / Stroke 17:294~299
Vila N / 2000 / Proinflammatory cytokines and early neurological worsening in ischemic stroke / Stroke 31:2325~2329
Whiteley W / 2009 / Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin-6 / PLoS Med 6:e1000145
Tripodi A / 2011 / D-dimer testing in laboratory practice / Clin Chem 57:1256~1262
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