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Simultaneous analysis of nitrosamines by headspace-GC-MS combined with inhibition of nitrosation by using nitrite scavenger
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Type
Proceeding
Author
Su Hyeon Hwang (Kyung Hee University) Chaeyoung Seo (Kyung Hee University) Minsun Jeong (Kyung Hee University) SangIn Lee (Kyung Hee University) Jongki Hong (Kyung Hee University)
Journal
The Korean Society of Analytical Sciences 한국분석과학회 학술대회 The 67th Biannual Conference of The Korean Society of Analytical Sciences
Published
2021.11
Pages
141 - 141 (1page)

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Simultaneous analysis of nitrosamines by headspace-GC-MS combined with inhibition of nitrosation by using nitrite scavenger
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Research history (2)

2022

Inhibition of the nitrosamines in-situ formation in active pharmaceutical ingredients by nitrite scavenger during HS-GC-MS analysis
Su Hyeon Hwang ,  Eun Jae Kim ,  Jongki Hong 한국분석과학회 학술대회 2022.05 Proceeding

2021

Simultaneous analysis of nitrosamines by headspace-GC-MS combined with inhibition of nitrosation by using nitrite scavenger
Su Hyeon Hwang ,  Chaeyoung Seo ,  Minsun Jeong and others 2 한국분석과학회 학술대회 2021.11 Proceeding
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N-nitrosamines including N-nitrosodimethylamine (NDMA) are classified as potentially carcinogenic substances in humans by the International Agency for Research on Cancer (IARC). In our previous study, we established solvent free headspace – gas chromatography – mass spectrometry (HS-GC-MS) applying stable - isotope dillution analysis method for determination of nine N-nitrosamines in various active pharmaceutical ingredient (APIs) and drug products. However, we observed huge amount of NDMA in some of drugs such as metformin, nizatidine and ranitidine due to in situ formation exposed to high temperature in HS-GC-MS system. This can lead to overestimation and low reproducibility of NDMA quantification results. To overcome the artefactual formation of NDMA during high temperature GC/MS analysis, we developed ... View All
#N-nitrosodimethylamine (NDMA) #N-nitrosamines #carcinogenic impurity #drug product #HS-GC-MS #nitrosation inhibitors #inhibitionof NDMA in situ formation

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Inhibition of the nitrosamines in-situ formation in active pharmaceutical ingredients by nitrite scavenger during HS-GC-MS analysis
Su Hyeon Hwang ,  Eun Jae Kim ,  Jongki Hong 한국분석과학회 학술대회 2022 .05

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