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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.5 No.3
- 발행연도
- 2015.1
- 수록면
- 172 - 180 (9page)
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초록· 키워드
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The adhesion of cells to an extracellular matrix is a dynamicprocess involving structural and signaling proteins, that, inturn, regulate key cellular processes, including migration,gene expression, differentiation and signaling. Integrins playimportant roles as primary adhesion receptors, and integrinmediatedcell adhesion sites can be differentiated, based onsize and location, into nascent adhesions, focal complexes,focal adhesions, and fibrillar adhesions. The formation ofnascent adhesions to a surface requires the bending of themembrane toward a surface, diffusion of integrins to the areaof close contact, and molecular adhesion. Each of theseprocesses is sensitive to the lipid make up of the membrane. Therefore, the lipid bilayer may exert significant control overthe dynamics of nascent adhesion formation. In this review,we consider the structure and components of cellularadhesions and lipid bilayers. We then review membraneproperties of bending rigidity, viscosity, and thickness thatare thought to have a central role in the formation of nascentcell adhesions via membrane curvature, redistribution ofintegrins, and bond formation.
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참고문헌 (67)
참고문헌 신청
Wozniak MA / 2004 / Focal adhesion regulation of cell behavior / Biochim Biophys Acta 1692(2-3):103~119
Gardel ML / 2010 / Mechanical integration of actin and adhesion dynamics in cell migration / Annu Rev Cell Dev Biol 26:315~333
Humphries JD / 2006 / Integrin ligands at a glance / J Cell Sci 119(Pt 19):3901~3903
Yamada KM / 2003 / Dimensions and dynamics in integrin function / Braz J Med Biol Res 36(8):959~966
Zaidel-Bar R / 2004 / Hierarchical assembly of cell-matrix adhesion complexes / Biochem Soc Trans 32(Pt3):416~420
Gardel ML / 2010 / Mechanical integration of actin and adhesion dynamics in cell migration / Annu Rev Cell Dev Biol 26:315~333
Humphries JD / 2006 / Integrin ligands at a glance / J Cell Sci 119(Pt 19):3901~3903
Yamada KM / 2003 / Dimensions and dynamics in integrin function / Braz J Med Biol Res 36(8):959~966
Zaidel-Bar R / 2004 / Hierarchical assembly of cell-matrix adhesion complexes / Biochem Soc Trans 32(Pt3):416~420
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