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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 22 - 28 (7page)
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Purpose: Neoadjuvant chemotherapy (NAC) has been recentlyused to downstage breast cancer. However, in patients with initialaxillary lymph node (ALN) metastasis, ALN dissection regardlessof the NAC response remains the standard treatment. Thepurpose of this study was to identify the feasibility and accuracyof sentinel lymph node biopsy (SLNB) after NAC in patients withALN metastasis at diagnosis. Methods: From January 2007 toAugust 2013, data of patients who were diagnosed with invasivebreast cancer and ALN metastasis and treated with NAC followedby definitive surgery in two centers were collected retrospectively.
A total of 386 patients were enrolled and classifiedinto five groups according to surgical procedure for the ALNsand pathologic results. Results: At SLNB after NAC, sentinellymph nodes (SLNs) that stained blue or were hot, includingsuspicious nodes, were identified; the SLN identification andfalse-negative rates was 96% and 10%, respectively. There wasno difference in the overall survival among the groups. For patientswho revealed a pathologic complete node response, there was asignificant difference in the disease-free survival rate betweenthe SLNB only and complete ALN dissection groups (p=0.031).
However, the rate of axillary recurrence demonstrated no significantdifferences among the groups (p>0.050) Conclusion:SLNB after NAC in breast cancer patients with initial ALN metastasismay help identify downstaging to negative nodal status andthereby reduce the surgical morbidity by avoiding standard ALNdissection.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Veronesi U / 2003 / A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer / N Engl J Med 349:546~553
Chen AM / 2004 / Breast conservation after neoadjuvant chemotherapy : the MD Anderson Cancer Center experience / J Clin Oncol 22:2303~2312
Loibl S / 2006 / Surgical procedures after neoadjuvant chemotherapy in operable breast cancer : results of the GEPARDUO trial / Ann Surg Oncol 13:1434~1442
Kuerer HM / 1999 / Incidence and impact of documented eradication of breast cancer axillary lymph node metastases before surgery in patients treated with neoadjuvant chemotherapy / Ann Surg 230:72~78
Kuerer HM / 1998 / Role of axillary lymph node dissection after tumor downstaging with induction chemotherapy for locally advanced breast cancer / Ann Surg Oncol 5:673~680
Chen AM / 2004 / Breast conservation after neoadjuvant chemotherapy : the MD Anderson Cancer Center experience / J Clin Oncol 22:2303~2312
Loibl S / 2006 / Surgical procedures after neoadjuvant chemotherapy in operable breast cancer : results of the GEPARDUO trial / Ann Surg Oncol 13:1434~1442
Kuerer HM / 1999 / Incidence and impact of documented eradication of breast cancer axillary lymph node metastases before surgery in patients treated with neoadjuvant chemotherapy / Ann Surg 230:72~78
Kuerer HM / 1998 / Role of axillary lymph node dissection after tumor downstaging with induction chemotherapy for locally advanced breast cancer / Ann Surg Oncol 5:673~680
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