지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Ankylosing spondylitis (AS) is the prototype of spondyloarthritis which shares complex clinical phenotypes and risk factors, both genetic and environmental with other chronic inflammatory disease, e.g. inflammatory bowel disease. Human leukocyte antigen-B27 has been known to be the major AS-susceptibility gene for more than 40 years and these molecules have distinct quaternary structures and biogenesis; at least three different hypotheses regarding the contributions to pathogenesis have been proposed. Advances in the discovery of novel susceptibility genes have pointed towards important biological pathways likely responsible for AS pathogenesis. As such, strong involvement of interleukin (IL)-23/IL-17 pathway has been hypothesized. The disease is characterized by inflammation and ankylosis, mainly at the cartilage−bone interface and enthesis. Besides the genetic background, environmental triggers such as microorganisms and mechanical stress are emerging as initiating and perpetuating factors for AS. Current concepts regard new bone formation at the enthesis as a pathological response to biomechanical stress and microbial consequences such as dysbiosis in gut inflammation.
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참고문헌 (41)
참고문헌 신청
Tsui FW. / 2014 / The genetic basis of ankylosing spondylitis : new insights into disease pathogenesis / Appl Clin Genet 7:105~115
Smith JA. / 2014 / Review : The interleukin-23/ interleukin-17 axis in spondyloarthritis pathogenesis : Th17 and beyond / Arthritis Rheumatol 66:231~241
Costello ME. / 2013 / Microbes, the gut and ankylosing spondylitis / Arthritis Res Ther 15:214
Jacques P. / 2014 / The role of mechanical stress in the pathogenesis of spondyloarthritis and how to combat it / Best Pract Res Clin Rheumatol 28:703~710
Colbert RA. / 1993 / Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide / Proc Natl Acad Sci U S A 90:6879~6883
Smith JA. / 2014 / Review : The interleukin-23/ interleukin-17 axis in spondyloarthritis pathogenesis : Th17 and beyond / Arthritis Rheumatol 66:231~241
Costello ME. / 2013 / Microbes, the gut and ankylosing spondylitis / Arthritis Res Ther 15:214
Jacques P. / 2014 / The role of mechanical stress in the pathogenesis of spondyloarthritis and how to combat it / Best Pract Res Clin Rheumatol 28:703~710
Colbert RA. / 1993 / Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide / Proc Natl Acad Sci U S A 90:6879~6883
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