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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 167 - 174 (8page)
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To investigate the clinical findings upon initial diagnosis and extraglandular manifestations in Korean patients with primary Sjögren’s syndrome (pSS). Methods. We collected clinical and laboratory data from 238 pSS patients enrolled at Seoul National University Hospital, Seoul National University Bundang Hospital and Seoul Medical Center from March 2011 to December 2014. All patients met the American-European Consensus Group criteria for pSS. Results. Upon initial diagnosis, sicca symptoms (xerophthalmia or xerostomia) as the chief complaint were only observed in 129 (54.2%) pSS patients, while extraglandular manifestation was more common as the chief complaint in male patients or those with younger age (＜40 years) than female or older patients (both p＜0.05). Extraglandular manifestations were found in 178 (74.8%) patients, with musculoskeletal manifestations being most common (53.8%). Peripheral neuropathy in pSS patients was associated with Raynaud phenomenon and elevated serum total immunoglobulin G (IgG) levels (both p＜0.05). Serum β2-microglobulin (β2-M) levels were significantly correlated with European League against Rheumatism (EULAR) Sjögren’s syndrome disease activity index, erythrocyte sedimentation rate and serum total IgG (all p＜0.001), and were higher in patients with extraglandular manifestations than those without (p＜0.05). Serum C3 levels were decreased in patients with extraglandular manifestation, compared to those without (p＜0.05). Malignant lymphoma was found in Korean pSS patients (1.7%) and associated with elevated serum β2-M levels (p＜0.0001). Conclusion. Extraglandular manifestations were common in pSS patients and may be a diagnostic tool for male or younger pSS patients. Serum β2-M levels can be useful markers for monitoring pSS patients.
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참고문헌 (24)
참고문헌 신청
Moutsopoulos HM. / 1994 / Sjögren's syndrome : autoimmune epithelitis / Clin Immunol Immunopathol 72:162~165
Venables PJ. / 2004 / Sjögren's syndrome / Best Pract Res Clin Rheumatol 18:313~329
Baimpa E. / 2009 / Hematologic manifestations and predictors of lymphoma development in primary Sjögren syndrome : clinical and pathophysiologic aspects / Medicine(Baltimore) 88:284~293
Voulgarelis M. / 2008 / Mortality in Sjögren's syndrome / Clin Exp Rheumatol 26(5 Suppl 51):S66~S71
Vitali C. / 2002 / Classification criteria for Sjögren's syndrome : a revised version of the European criteria proposed by the American-European Consensus Group / Ann Rheum Dis 61:554~558
Venables PJ. / 2004 / Sjögren's syndrome / Best Pract Res Clin Rheumatol 18:313~329
Baimpa E. / 2009 / Hematologic manifestations and predictors of lymphoma development in primary Sjögren syndrome : clinical and pathophysiologic aspects / Medicine(Baltimore) 88:284~293
Voulgarelis M. / 2008 / Mortality in Sjögren's syndrome / Clin Exp Rheumatol 26(5 Suppl 51):S66~S71
Vitali C. / 2002 / Classification criteria for Sjögren's syndrome : a revised version of the European criteria proposed by the American-European Consensus Group / Ann Rheum Dis 61:554~558
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