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자료유형
학술저널
저자정보
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.29 No.8
발행연도
2014.1
수록면
1,126 - 1,131 (6page)

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Pulmonary surfactant (PS) therapy was proven to be highly successful for the treatment ofrespiratory distress syndrome in premature infants. As a results, early prophylactic (EP) PStherapy has been introduced recently in Europe, the US and Korea. However, no multicenterstudy was compared EP and late selective (LS) PS therapies in Korea. We performeda retrospective multi-center study to compare the outcomes of EP and LS PS therapies invery preterm infants. We analyzed clinical morbidity and mortality for 1,291 infants in2010 (LS group) and 1,249 infants in 2011 (EP group); the infants were born < 30 weeksof gestation and had birth weight ≤ 1,250 g, and were chosen from 53 neonatal intensivecare units in Korea. Compared to the LS group (22.5%), the overall mortality was better inthe EP group (19.9%) and there was no increased need for retreatment.There wereadditional benefits in the EP group such as fewer associated complications. To the best ofknowledge, our study is the first nationwide Korean study to compare the outcomes of EPand LS therapies, and it provides evidences that EP PS therapy is important in very preterminfants to improve for survival and reduce morbidities.

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