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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 167 - 172 (6page)
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The correlation between serum anti-tuberculosis (TB) drug levels and the drug-inducedhepatotoxicity (DIH) remains unclear. The purpose of this study was to investigate whetheranti-TB DIH is associated with basal serum drug levels. Serum peak levels of isoniazid (INH),rifampicin (RMP), pyrazinamide (PZA), and ethambutol (EMB) were analyzed in bloodsamples 2 hr after the administration of anti-TB medication. Anti-TB DIH and mild liverfunction test abnormality were diagnosed on the basis of laboratory and clinical criteria.
Serum anti-TB drug levels and other clinical factors were compared between thehepatotoxicity and non-hepatotoxicity groups. A total of 195 TB patients were included inthe study, and the data were analyzed retrospectively. Seventeen (8.7%) of the 195patients showed hepatotoxicity, and the mean aspartate aminotransferase/alanineaminotransferase levels in the hepatotoxicity group were 249/249 IU/L, respectively.
Among the 17 patients with hepatotoxicity, 12 showed anti-TB DIH. Ten patients showedPZA-related hepatotoxicity and 2 showed INH- or RMP-related hepatotoxicity. However,intergroup differences in the serum levels of the 4 anti-TB drugs were not statisticallysignificant. Basal serum drug concentration was not associated with the risk anti-TB DIH inpatients being treated with the currently recommended doses of first-line anti-TBtreatment drugs.
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참고문헌 (32)
참고문헌 신청
World Health Organization / 2012 / Global tuberculosis report 2012
World Health Organization / 2010 / Treatment of tuberculosis: guidelines / World Health Organization
Blumberg HM / 2003 / American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America : treatment of tuberculosis / Am J Respir Crit Care Med 167:603~662
Yee D / 2003 / Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis / Am J Respir Crit Care Med 167:1472~1477
Tostmann A / 2008 / Antituberculosis drug-induced hepatotoxicity : concise up-to-date review / J Gastroenterol Hepatol 23:192~202
World Health Organization / 2010 / Treatment of tuberculosis: guidelines / World Health Organization
Blumberg HM / 2003 / American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America : treatment of tuberculosis / Am J Respir Crit Care Med 167:603~662
Yee D / 2003 / Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis / Am J Respir Crit Care Med 167:1472~1477
Tostmann A / 2008 / Antituberculosis drug-induced hepatotoxicity : concise up-to-date review / J Gastroenterol Hepatol 23:192~202
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