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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 808 - 815 (8page)
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This study was aimed to evaluate the ability of imaging parameters measured on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted MRI (DWI) and positron emission tomography/computed tomography (PET/CT) to serve as response markers in breast cancer after neoadjuvant chemotherapy (NAC). In 20 patients with breast cancer, DCE-MRI and DWI using a 3 T scanner and PET/CT were performed before and after NAC. DCE-MRI was analyzed using an automatic computer-aided detection program (MRCAD). The response imaging parameters were compared with the pathologic response. The areas under the curve (AUCs) for DCE-MRI using MR-CAD analysis, DWI and PET/CT were 0.77, 0.59 and 0.76, respectively. The combination of all parameters measured by MRCAD showed the highest diagnostic performance and accuracy (AUC = 0.77, accuracy = 90%). The combined use of the parameters of PET/CT with DCE-MRI or DWI showed a trend toward improved specificity and negative predictive value (100%, 100%, accuracy = 87.5%). The use of DCE-MRI using MR-CAD parameters indicated better diagnostic performance in predicting the final pathological response compared with DWI and PET/CT, although no statistically significant difference was observed. The combined use of PET/CT with DCE-MRI or DWI may improve the specificity for predicting a pathological response.
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참고문헌 (17)
참고문헌 신청
Mauri D / 2005 / Neoadjuvant versus adjuvant systemic treatment in breast cancer : a meta-analysis / J Natl Cancer Inst 97:188~194
Kong X / 2011 / Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable prognosis for breast cancer patients / Eur J Cancer 47:2084~2090
Gonzalez-Angulo AM / 2007 / Overview of resistance to systemic therapy in patients with breast cancer / Adv Exp Med Biol 608:1~22
Drew PJ / 1999 / Dynamic contrast enhanced magnetic resonance imaging of the breast is superior to triple assessment for the pre-operative detection of multifocal breast cancer / Ann Surg Oncol 6:599~603
Van Goethem M / 2007 / MR mammography is useful in the preoperative locoregional staging of breast carcinomas with extensive intraductal component / Eur J Radiol 62:273~282
Kong X / 2011 / Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable prognosis for breast cancer patients / Eur J Cancer 47:2084~2090
Gonzalez-Angulo AM / 2007 / Overview of resistance to systemic therapy in patients with breast cancer / Adv Exp Med Biol 608:1~22
Drew PJ / 1999 / Dynamic contrast enhanced magnetic resonance imaging of the breast is superior to triple assessment for the pre-operative detection of multifocal breast cancer / Ann Surg Oncol 6:599~603
Van Goethem M / 2007 / MR mammography is useful in the preoperative locoregional staging of breast carcinomas with extensive intraductal component / Eur J Radiol 62:273~282
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