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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 441 - 449 (9page)
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초록· 키워드
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Myostatin (MSTN), also known as the growth differentiation factor-8 (GDF-8), belongs to the transforming growth factor-b superfamily. MSTN is a negative regulator of muscle development in vertebrates. However, the transcriptional regulation of MSTN in freshwater crustaceans is still unclear. In this study, a cDNA encoding for MSTN/GDF11 (Mn-MSTN/GDF11) was cloned from the oriental freshwater shrimp, Macrobrachium nipponense.
The full-length cDNA sequence of Mn-MSTN/ GDF11 was composed of 1733 nucleotides, including a 50 UTR of 119 nucleotides, an open read frame of 1359 nucleotides, and a 30 UTR of 255 nucleotides. The predicted peptide of Mn-MSTN/GDF11 has 452 amino acids with the conserved RXXR cleavage site and nine cysteines. Tissuespecific expression pattern showed that Mn-MSTN/GDF11 is mainly expressed in abdominal muscle. During the course of embryonic development, expression level of Mn- MSTN/GDF11 could be detected after gastrul stage, and reached at the highest level at embryonized-zoea stage.
During molt cycle, expression level of Mn-MSTN/GDF11 mRNA was up-regulated significantly at early postmoult stage, but down-regulated gradually in the following molt stages. In the period of 14 days after eyestalk ablation, Mn- MSTN/GDF11 transcripts were significantly decreased in abdominal muscle and heart, but increased in thoracic muscle. The results of this study indicated that Mn-MSTN/ GDF11 may play a role in molt cycle and be regulated by hormone secreted in eyestalk.
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참고문헌 (42)
참고문헌 신청
Chang ES / 2011 / Regulation of crustacean molting: a review and our perspectives / Gen Comp Endocrinol 172:323~330
Covi JA / 2010 / Molt cycle regulation of protein synthesis in skeletel muscle of the blackback land crad, Gecarcinus lateralis, and the differential expression of a myostatin-like factor during atrophy induced by molting or unweighting / J Exp Biol 213:172~183
Covi JA / 2008 / Expression of alternatively spliced transcripts for a myostatin-like protein in the blackback land crab, Gecarcinus lateralis / Comp Biochem Phys A 150:423~430
De santis C / 2007 / Candidate growth genes in finfish-where should we be looking? / Aquaculture 272:22~38
De Santis C / 2011 / Growing backwards: an inverted role for the shrimp ortholog of vertebrate myostatin and GDF11 / J Exp Biol 214:2671~2677
Covi JA / 2010 / Molt cycle regulation of protein synthesis in skeletel muscle of the blackback land crad, Gecarcinus lateralis, and the differential expression of a myostatin-like factor during atrophy induced by molting or unweighting / J Exp Biol 213:172~183
Covi JA / 2008 / Expression of alternatively spliced transcripts for a myostatin-like protein in the blackback land crab, Gecarcinus lateralis / Comp Biochem Phys A 150:423~430
De santis C / 2007 / Candidate growth genes in finfish-where should we be looking? / Aquaculture 272:22~38
De Santis C / 2011 / Growing backwards: an inverted role for the shrimp ortholog of vertebrate myostatin and GDF11 / J Exp Biol 214:2671~2677
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